DEKOFLU-PLUS Tablet

- Relief of nasal and sinus congestion.

- Relief of allergic symptoms of the nose or throat due to upper respiratory tract allergies.

- Relief of sinus pain and headache.

- Adjunct with antibacterials in sinusitis, tonsillitis and otitis media.

Dosage & Administration

As directed by physician.

- Hypersensitivity to any of the ingredients of the formulation.

- Severe hypertension.

Hypersensitive individuals may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness and nausea. Use of sympathomimetics has been associated with fear, anxiety, restlessness, tremor, weakness, dysuria, insomnia, hallucinations and convulsions.

Clinically significant drug interactions may occur on concomitant administration of this tablet with monoamine oxidase inhibitors, tricyclic antidepressants, beta-adrenergic agents, methyldopa, reserpine and veratrum alkaloids.

In case a hypersensitivity reaction occurs which is rare, this tablet should be discontinued. This medicine contains Paracetamol and therefore should not be used in conjunction with other Paracetamol containing products. This tablet should be used with caution in patients with renal or hepatic dysfunction, diabetes mellitus, hyperthyroidism, cardiovascular problems, epilepsy and closed angle glaucoma. It is advisable not to drive or operate machinery when on treatment with this medicine.

Paracetamol produces analgesia by elevation of the pain threshold and antipyretic effect through action on the hypothalamic heart-regulating center. Paracetamol is equal to aspirin in analgesic and antipyretic effectiveness, and it is unlikely to produce many of the side effects associated with aspirin and aspirin-containing products. Sympathomimetic decongestants reduce the nasal congestion due to increased nasal blood flow associated with colds and influenza.

Levocetirizine is a third-generation non-sedative antihistamine indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis and uncomplicated skin manifestations of chronic idiopathic urticaria. It was developed from the second-generation antihistamine cetirizine.

Caffeine is most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling.

Phenylephrine is sympathomimetic vasoconstrictor that has been used as a decongestant. It is relatively selective alpha-adrenoceptor agonist. The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors and relatively little is due to an indirect effect via release of nonadrenaline. Its pressoraction is weaker than that of noradrenaline but of longer duration. At therapeutic doses, it does not cause significant stimulation of the central nervous system.