HORF Lozenge

For the prophylaxis of stomatitis, gangrenous stomatitis, pharyngitis, laryngitis, tonsillitis, gingivitis, post-tonsillectomy and post tooth extraction secondary bacterial infections. For the temporary local relief of pain associated with dental conditions and sore throats.

Dosage and Administration

For prevention: 1 lozenge 4-5 times daily.

Place the lozenge on the tongue and let it dissolve slowly for longer bactericidal action.

To be dispensed on physician’s prescription.

In patients with a history of hypersensitivity to Chlorhexidine and Benzocaine.

Irritation or other adverse reactions such as dermatitis or photosensitivity are rare. Blackness or soreness of the tongue may occur, usually disappears when therapy is stopped. Methemoglobinemia has been reported to occur rarely in infants and children after administration.

1. If symptoms persist, or irritation develops, discontinue medication and consult a physician.

2. Generally, the lozenges should not be used for self-medication longer than 2 days or in children younger than 3 years of age, unless directed by physician.

1. Chlorhexidine is a biguanide disinfectant which is effective against a wide range of vegetative Gram-positive and Gram-negative bacteria, and it is more effective against Gram-positive than Gram-negative bacteria

2. Chlorhexidine is absorbed onto the cell walls of microorganisms, which causes leakage of intracellular components. At low concentrations Chlorhexidine is a bacteriostatic, at higher concentrations, Chlorhexidine is a bactericidal.

3. Because of its positive charge, Chlorhexidine is absorbed during oral rinsing on the surfaces of teeth, plague, and oral mucosa, which have a net negative charge. Subsequently, the absorbed medication is gradually released from these sites by diffusion for up to 24 hours as the concentration of Chlorhexidine in the salvia decreases. This release provides a continuing bacteriostatic effect.

4. Benzocaine is a surface anesthetic of the ester type with low systemic toxicity. It also used in combination of Chlorhexidine for the local relief of pain associated with dental conditions; sore throats.