DECOLGEN NON-DROWSE Tablet

Hypersensitive to any component in the formulation

Severe renal and hepatic insufficiency, severe cardiovascular disease, myocardial infarction, coronary artery disease, severe hypertension, atrioventricular block, ventricular tachycardia, severe hyperthyroidism, angle-closure glaucoma.

Acetaminophen usually is well tolerated. Skin rash and other allergic reactions occur occasionally.

The rash is usually erythematosus or urticarial, but sometimes it is more serious and may be accompanied by drug fever and mucosal lesions.

Phenylephrine may cause mild CNS stimulation, especially in patients who are hypersensitive to the effects of sympathomimetic drugs.

Please inform your doctor of all undesirable effects upon drug administration.

Taking acetaminophen at high dose in a long time with anticoagulant medicines (such as coumarin, indandion derivatives) concomitantly, effects of anticoagulant medicines improve slightly.

Chronic excessive alcohol consumption can increase the potential hepatic toxicity of acetaminophen.

Safe use of drug during pregnancy has not been established. The drug may be distributed into milk and should not be given to nursing women because infants may be especially susceptible to its effect.

Acetaminophen is relatively nontoxic in therapeutic doses. Dermatologic reactions including pruritic maculopapular rash and urticaria have been reported.

Acetaminophen (paracetamol) has been associated with a risk of rare but serious skin reactions.

Physicians have to inform patients about the signs of serious skin reactions are known as Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell syndrome, and acute generalized exanthematous pustulosis (AGEP).

Patients should be discontinued the product at first appearance of skin rush or any other sign of hypersensitivity.

Other sensitivity reactions including laryngeal edema, angioedema, and anaphylactoid reactions may occur rarely. Phenylephrine should be used with caution in geriatric patients, patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease, or severe arteriosclerosis, type 1 diabetes mellitus.

PHENYLEPHRINE acts directly on α-adrenergic receptors in the mucosa of the respiratory tract producing vasoconstriction which results in shrinkage of swollen nasal mucous membranes, reduction of edema, tissue hyperemia, nasal congestion and an increase in nasal airway patency, especially where cannot be reached by sprays, drops or topical applications.

ACETOAMINOPHEN – a non-narcotic analgesic-antipyretic drug. It raises the pain threshold to check headache, muscle and joint pains, and general malaise frequently associated with the common cold.