COVERSYL PLUS 10mg/2.5mg Tablet

គុណភាពព្យាបាល
ឱសថនេះមានសារជាតិសកម្ម2មុខ មានមុខងារបញ្ចុះសម្ពាធឈាមនិងបញ្ចុះទឹកនោមស្ថិតក្នុងក្រុម ACE Inhibitor ប្រើសម្រាប់ព្យាបាលជម្ងឺសម្ពាធឈាមឡើង។
កំរិត និងរបៀបប្រើ ត្រូវអនុវត្តតាមវេជ្ជបញ្ជា
- មនុស្សពេញវ័យ: កម្រិតប្រើធម្មតាគឺ លេបម្ដង 1 គ្រាប់ 1ថ្ងៃ 1ដង នៅពេលព្រឹកមុនបាយជាមួយទឹក 1 កែវ។
- កំណត់សំគាល់: ឱសថនេះត្រូវលេបទាំងមូល ជាមួយទឹកគ្រប់គ្រាន់ (1កែវ) នៅពេលដដែល។ មិនត្រូវឈប់ប្រើឱសថ ដោយគ្មានវេជ្ជបញ្ជាពីគ្រូពេទ្យទេ។

Indication:
It is an antihypertensive and is used in the treatment of high blood pressure (hypertension).

Dosage:

Always take COVERSYL PLUS 10mg/2.5mg exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The usual dose is one tablet daily. Take your tablet preferably in the morning and before a meal. Swallow the tablet with a glass of water.

ហាមប្រើ ចំពោះ

- អ្នកងាយមានប្រតិកម្មអាល្លែកហ្ស៊ីជាមួយឱសថនេះ និងក្រុម ACE inhibitor

- អ្នក ឬសមាជិកគ្រួសារអ្នក ធ្លាប់មានប្រតិកម្មអាល្លែកហ្ស៊ីជា ដូចជា ដង្ហក់ ហើមមុខហើមមាត់ ឡើងកន្ទួល ក្រហម រមាស់ ដោយប្រើឱសថក្រុម ACE inhibitor

- អ្នកមានជំងឺធ្ងន់ធ្ងរ អ្នកខ្សោយតម្រងនោមធ្ងន់ធ្ងរ អ្នកលាងឈាម

- អ្នកខ្សោយបេះដូងខ្លាំង ហើមខ្លាំងពិបាកដកដង្ហើម

- អ្នកមានផ្ទៃពោះលើសពី3ខែ ស្ត្រីអាចមានផ្ទៃពោះ និងកុមារ។

- if you are allergic to perindopril or any other ACE inhibitor, or to indapamide or any other sulphonamides or any of the other ingredients of COVERSYL PLUS 10mg/2.5mg,

- if you have experienced symptoms such as wheezing, swelling or the face or tongue, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema),

- if you have severe liver disease or suffer from a condition called hepatic encephalopathy (degenerative disease of the brain),

- if you have a kidney disease or if you are receiving dialysis,

- if you have low or high blood potassium,

- if you are suspected of having untreated decompensated heart failure (severe water retention, difficulty in breathing),

- if you are more than 3 months pregnant (it is also better to avoid COVERSYL PLUS 10mg/2.5mg in early pregnancy),

- if you are breast-feeding.

ផលរំខាន
ត្រូវប្រាប់គ្រូពេទ្យអោយបានដឹង ប្រសិនបើអ្នកមានផលរំខានដូចជា ហើមមុខហើមមាត់ ពិបាកដកដង្ហើម ធីងធោងខ្លាំង ពិបាករំលាយអាហារ បេះដូងលោតញាប់ បេះដូងលោតខ្លាំង ឈឺក្បាល វិលមុខ ងងឹតមុខពេលងើបឈរ(ដោយសម្ពាធឈាមចុះ) ស្រវាំងភ្នែក ហ៊ឹងត្រចៀក ក្អក ដកដង្ហើមញាប់ ចង្អោរ ឈឺពោះ ស្ងួតមាត់ ពិបាករំលាយអាហារ រាក ទល់លាមក រមាស់ ឡើងកន្ទួលក្រហម រមួលសាច់ដុំ អស់កម្លាំង។ ក្នុងករណីកម្រ អាចមានប្រតិកម្មអាល្លែកហ្ស៊ី ដូចជា ដង្ហក់ ហើមមុខហើមមាត់ ឡើងកន្ទួលក្រហម រមាស់

If you experience any of the following, stop taking the medicinal product at once and tell your doctor immediately:

- swelling of the face, lips, mouth, tongue or throat, difficulty in breathing,

- severe dizziness or fainting,

- unusual fast or irregular heart beat.

In decreasing order of frequency, side effects can include:

- Common:

headache, dizziness, vertigo, pins and needles, vision disturbances, tinnitus (sensation of noises in the ears), light-headedness due to low blood pressure, cough, shortness of breath, gastro-intestinal disorders (nausea, vomiting, abdominal pain, taste disturbances, dry mouth, dyspepsia or difficulty of digestion, diarrhoea, constipation), allergic reactions (such as skin rashes, itching), muscle cramps, feeling of tiredness,

- Uncommon:

mood swings, sleep disturbances, bronchospasm (tightening of the chest, wheezing and shortness of breath), angioedema (symptoms such as wheezing, swelling of the face or tongue), urticaria, purpura (red pinpoints on skin), kidney problems, impotence, sweating,

- Very rare:

confusion, cardiovascular disorders (irregular heart beat, angina, heart attack), eosinophilic pneumonia (a rare type of pneumonia), rhinitis (blocked up or runny nose), severe skin manifestations such as erythema multiforme. If you suffer from systemic lupus erythematosus (a type of collagen disease), this might get worse. Cases of photosensitivity reactions (change in skin appearance) after exposure to the sun or artificial UVA have also been reported.

- Not known:

fainting, life-threatening irregular beat (Torsade de Pointes), abnormal ECG heart tracing, increased levels of liver enzymes.

Disorders of the blood, kidney, liver or pancreas and changes in laboratory parameters (blood tests) can occur. Your doctor may need to give you blood tests to monitor your condition.

In cases of hepatic insufficiency (liver problems), there is a possibility of onset of hepatic encephalopathy (degenerative disease in the brain).

អន្តរកម្មឱសថ
ប្រសិនបើមានប្រើឱសថផ្សេងខាងក្រោម ត្រូវប្រាប់គ្រូពេទ្យអោយបានដឹង ជៀសវាងមានអន្តរកម្ម ដូចជា ឱសថLithium, Spironolactone, Antihypertensor, Procainamide, Allopurinol, Terfenadine, Corticoid, Immunosuppressant, Anticytotic, Erythromycin inj, Halofantrine, Pentomidine, Vincamine, Bepridil, Sultopride, Quinidine, Amiodarone, Digoxin, Insulin, Metformin, Calcium, NSAID, Amphotericin.
 

You should avoid COVERSYL PLUS 10mg/2.5mg with:

- lithium (used to treat depression),

- potassium-sparing diuretics (spironolactone, triamterene), potassium salts.

Make sure to tell your doctor if you are taking any of the following medicines as special care may be required:

- other medicines for treating high blood pressure,

- procainamide (for the treatment of an irregular heart beat),

- allopurinol (for the treatment of gout),

- terfenadine or astemizole (antihistamines for hay fever or allergies),

- corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis,

- immunosupressants used for the treatment of auto-immune disorders or following transplant surgery to prevent rejection (e.g. ciclosporin),

- medicines for the treatment of cancer,

- erythromycin by injection (an antibiotic),

- halofantrine (used to treat certain types of malaria),

- pentamidine (used to treat pneumonia),

- vincamine (used to treat symptomatic cognitive disorders in elderly including memory loss),

- bepridil (used to treat angina pectoris),

- sultopride (for the treatment of psychoses),

- medicines used for heart rhythm problems (e.g. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol),

- digoxin or other cardiac glycosides (for the treatment of heart problems),

- baclofen (to treat muscle stiffness occurring in diseases such as multiple sclerosis),

- medicines to treat diabetes such as insulin or metformin,

- calcium including calcium supplements,

- stimulant laxatives (e.g. senna),

- non-steroidal anti-inflammatory drugs (e.g. ibuprofen) of high dose salicylates (e.g. aspirin),

- amphotericin B by injection (to treat severe fungal disease),

- medicines to treat mental disorders such as depression, anxiety, schizophrenia… (e.g. tricyclic antidepressants, neuroleptics),

- tetracosactide (to treat Crohn’s disease).

ហាមប្រើចំពោះស្ត្រីមានផ្ទៃពោះ ឬមានបំណងនឹងមានផ្ទៃពោះ និង ចំពោះស្ត្រីបំបៅកូន។

Pregnancy

You must tell your doctor if you think that you are (or might become) pregnant.

Your doctor will normally advise you to stop taking COVERSYL PLUS 10mg/2.5mg before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of COVERSYL PLUS 10mg/2.5mg. COVERSYL PLUS 10mg/2.5mg is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.

Breast-feeding

Tell your doctor if you are breast-feeding or about to start breast-feeding. COVERSYL PLUS 10mg/2.5mg is contra-indicated for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.

See your doctor immediately.

ការប្រុងប្រយ័ត្ន
- ត្រូវប្រាប់គ្រូពេទ្យអោយបាដឹង ប្រសិនបើអ្នកមានផ្ទៃពោះ បំបៅកូន ខ្សោយបេះដូង ខ្សោយថ្លើម អាយុក្រោម18ឆ្នាំ មានជំងឺទឹកនោមផ្អែម មានជំងឺស្ទះសរសៃឈាមបេះដូង ស្ទះសរសៃឈាមតម្រងនោម អាលែកហ្ស៊ីស្បែក ក្រិនសរសៃឈាម ឈឺសន្លាក់ឆ្អឹង(ប្រគ្រីវ) ត្រូវតមប្រៃ ត្រូវធ្វើការវះកាត់ រាករូសខ្លាំង ខ្វះជាតិទឹក ត្រូវលាងឈាម ត្រូវប្រើសារធាតុទប់កាំរស្មីX(Contrast agent) ត្រូវឆ្លងការត្រូតពិនិត្យថ្នាំញៀន(កីឡាករ) ឬមានប្រើឱសថផ្សេងៗ។
- ត្រូវជៀសវាងប្រើចំពោះ កុមារ និងក្មេងជំទង់ អាយុក្រោម18ឆ្នាំ។
- ត្រូវជៀសវាងប្រើឱសថនេះចំពោះ ស្ត្រីមានផ្ទៃពោះ លើកលែងតែមានវេជ្ជបញ្ជាពីគ្រូពេទ្យ។
- ត្រូវជៀសវាងប្រើឱសថនេះចំពោះ ស្ត្រីបំបៅកូន (បើចង់ប្រើ ត្រូវផ្អាកការបំបៅកូន)។
- ឱសថនេះអាចប៉ះពាល់ដល់សមត្ថភាពបើកបរ ឬការបញ្ជាម៉ាស៊ីន ពិសេសនៅពេលបង្កើនកម្រិតប្រើនិងពេលផឹកសុរា។
 

If any of the following apply to you please talk to your doctor before taking COVERSYL PLUS 10mg/2.5mg:

- if you have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood),

- if you have any other heart problems,

- if you have liver problems,

- if you suffer from a collagen disease (skin disease) such as systemic lupus erythematosus or scleroderma,

- if you have atherosclerosis (hardening of the arteries),

- if you suffer from hyperparathyroidism (overactive parathyroid gland),

- if you suffer from gout,

- if you have diabetes,

- if you are on a salt restricted diet or use salt substitutes which contain potassium,

- if you take lithium or potassium-sparing diuretics (spironolactone, triamterene) as their use with COVERSYL PLUS 10mg/2.5mg should be avoided.

You must tell your doctor if you think that you are (or might become) pregnant. COVERSYL PLUS 10mg/2.5mg is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage.

When you are taking COVERSYL PLUS 10mg/2.5mg, you should also inform your doctor or the medical staff:

- if you are to undergo anaesthesia and/or surgery,

- if you have recently suffered from diarrhoea or vomiting, or are dehydrated,

- if you are to undergo dialysis or LDL apheresis (which is removal of cholesterol from your blood by a machine),

- if you are going to have desensitization treatment to reduce the effects of an allergy to bee or wasp stings,

- if you are to undergo a medical test that requires injection of an iodinated contrast agent (a substance that makes organs like kidney or stomach visible on an X-ray).

Athletes should be aware that COVERSYL PLUS 10mg/2.5mg contains an active ingredient (indapamide) which may give a positive reaction in drug tests.

COVERSYL PLUS 10mg/2.5mg should not be given to children.

This medicine is a combination of two active ingredients, perindopril and indapamide. It is an anti-hypertensive and is used in the treatment of high blood pressure (hypertension). This medicine is prescribed for patients already receiving perindopril 10mg and indapamide 2.5mg from separate tablets, these patients may instead receive one tablet of COVERSYL PLUS 10mg/2.5mg which contains both ingredients.

Perindopril belongs to a class of medicines called ACE inhibitors. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Indapamide is a diuretic. Diuretics increase the amount of urine produced by the kidneys. However, indapamide is different from other diuretics, as it only causes a slight increase in the amount of urine produced. Each of the active ingredients reduces blood pressure and they work together to control your blood pressure.