ADVANTEC Tablet

ក្រុមហ៊ុនផលិតឱសថ:

 

Getz pharma, Pakistan

  • សារធាតុសកម្ម
  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់
  • ហាមប្រើ
  • ផលរំខាន
  • អន្តរប្រតិកម្ម
  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន
  • ការប្រុងប្រយ័ត្នជាពិសេស
  • សកម្មភាពឱសថ
  • បរិយាយប័ណ្ណឱសថ 
  • សារធាតុសកម្ម

  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់

    For the treatment of hypertension. The fixed dose combination is not indicated for initial therapy.

    Dosage and Administration

    The usual starting dose is 1 tablet per day with or without food.

    To minimize dose dependent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy.

    Dose Titration

    A patient whose blood pressure is not controlled on 25mg of hydrochlorothiazide once daily can expect an incremental effect from ADVANTEC. A patient whose blood pressure is controlled on 25mg of hydrochlorothiazide but is experiencing decreases in serum potassium can expect the same or incremental blood pressure effects from ADVANTEC and serum potassium may improve.

    See the package insert about the details below.

    Renal Impaired Patients

    Hepatic Impaired Patients

  • ហាមប្រើ

    - In patients who are hypersensitive to this drug or any component of this product.

    - In patients with anuria or hypersensitivity to other sulfonamide-derived drugs, due to hydrochlorothiazide component in the preparation.

    - In concomitant use with other antihypertensive drugs like, dofetilide.

    - In patients with more severe renal impairment.

  • ផលរំខាន

    Adverse reactions reported are mild and transient in nature and have only infrequently required discontinuation of therapy.

    Common

    Back pain, dizziness, flu-like symptoms, headache, upper respiratory infection.

    Less common

    Abdominal pain, change in amount of urine, increased sweating, unusual thirst, fainting, gastrointestinal disorders, mood swings.

    Rare

    Persistent sore throat, cough, fever, unusual fatigue, unusual bleeding or bruising, pale skin and eyes, dark urine, chest pain, irregular heartbeats, joint pain.

  • អន្តរប្រតិកម្ម

    See the package insert about the details below.

    Candesartan Cilexetil

    Lithium

    Hydrochlorothiazide

    When administered concurrently the following drugs may interact with thiazide diuretics

    Alcohol, barbiturates or narcotics

    Anti-diabetic (Oral agents and insulin)

    Cholestyramine and colestipol resins

    Corticosteroids, ACTH

    Pressor amines (norepinephrine)

    Skeletal muscle relaxant (tubocurarine)

    Lithium

    NSAIDs

  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន

    Pregnancy

    When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, ADVANTEC should be discontinued as soon as possible.

    Nursing Mothers

    Hydrochlorothiazide is excreted in breast milk but it is not known whether candesartan is excreted in human milk. Because of the potential for adverse effects or discontinue the drug, taking into account the importance of the drug to the mother.

  • ការប្រុងប្រយ័ត្នជាពិសេស

    See the package insert about the details below.

    Hypotension in Volume- and Salt-Depleted Patients

    Candesartan Cilexetil

    Impaired Renal Function

    Hydrochlorothiazide

    - Impaired hepatic function

    - Impaired renal function

    - Hypersensitivity reaction

    - Cause exacerbation or activation of systemic lupus erythematosus

    - Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.

    - Thiazides may decrease urinary calcium excretion.

  • សកម្មភាពឱសថ

    Candesartan Cilexetil

    Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensinⅡby selectively blocking the binding of angiotensinⅡto the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensinⅡsynthesis.

    Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensinⅡfrom angiotensinⅠ, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because candesartan does not inhibit ACE (kininaseⅡ), it does not affect the response to bradykinin. Candesartan does not bind to or block other hormone receptors or iron channels known to be important in cardiovascular regulation.

    Hydrochlorothiazide

    Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensinⅡ, so co-administration of an angiotensinⅡreceptor antagonist tends to reverse the potassium loss associated with these diuretics. The mechanism of the antihypertensive effect of thiazides is unknown.

*ព័ត៌មានឱសថត្រូវបានរៀបរៀងដោយ អ៊ីម៉ាតុគឹ មេឌីក (ខេមបូឌា) ដោយផ្អែកលើប្រភពព័ត៌មានខាងក្រោម។ សម្រាប់ព័ត៌មានលម្អិត សូមស្វែងរកនៅក្នុងក្រដាសព័ត៌មាននៃឱសថនីមួយៗ ឬ សាកសួរទៅកាន់ក្រុមហ៊ុនឱសថឬតំណាងចែកចាយនៃឱសថនីមួយៗ។

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