TRIME-S Capsule

Gastric of duodenal dyspepsia, secretion disorder of bile acid and pancreas, dyspepsia after gastrectomy or cholecystectomy, irritable bowel syndrome, atonic or enterokinetic constipation, indigestion due to gastrointestinal dyskinesia, functional diarrhea.

Dosage and administration

Adults: 2 capsules, 3 times daily before meals.

Patients with hypersensitivity to any component of the drug.

Gastrointestinal: Rarely constipation, diarrhea, nausea, vomiting, dyspepsia, dry mouth may occur.

Circulatory: Rarely palpitation may occur.

Psycho-nervous system: Rarely fatigue, burning sense, coldness, vertigo, malaise, headache and light hypnoidal state may occur.

Hepatic: Rarely elevation in GOT, GPT may occur.

Hypersensitivity: Rarely rash may occur. In the occurrence of the symptom, administration is discontinued.

Cisapride: Concomitant use of an anticholinergic agent with cisapride is likely to counteract gastrointestinal motility normally induced by cisapride.

Procainamide: Procainamide coadministered with Trimebutine may result in additive antivagal effects on atrio-ventricular nodal conduction.

Pregnancy

There are no adequate and well-controlled studies in pregnant women; therefore, this drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation

The safety of this drug in nursing mothers has not been established. Therefore this drug should be avoided in nursing mothers. However if inevitable, nursing should be discontinued.

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection.