AUROMIDE PLUS Eye drops

It is mainly indicated for ophthalmologic examinations like during ophthalmoscopy, slit-lamp examination, retinal photography, and prior ocular surgery. It is used as an adjunct in the treatment of anterior uveitis, in the management of anterior segment burns to dilate the pupils and prevent iris adhesions to the lens, in cycloplegic refraction, in the management of iridocyclitis associated with stromal keratitis, in the management of uveal inflammation associated with fungal keratitis.

Dosage and Administration

For ophthalmoscopy examination - 1-2 drops in the eye, 15-30 minutes prior to the procedure. For other indications the frequency of administration should be as per the direction of the physician.

The preparation is contraindicated in patients suffering from closed-angle glaucoma and hypersensitivity to any ingredient in the formulation.

On topical application there may be transient burning or stinging and lacrimation. Blurred vision, photophobia and allergic reactions may occur. Rarely systemic effects such as tachycardia, palpitations, headache, and tremors may occur.

Auromide Plus eye drops may interact with anesthetics (cyclopropane or halothane), beta adrenergic blocking agents, tricyclic anti depressants, propranolol, quanithidine, methyl dopa, sulphite sensitivities and anticholinergics.

It should be used only if clearly needed in pregnant and nursing women.

Warnings

Not for injection. Do not touch the nozzle tip to any surface, since this may contaminate the solution.

Precautions

This preparation should be used with caution in patients with cardiovascular disorders, in infants, children and elderly patients.

When the drug is topically applied to the eye, Phenylephrine directly acts on the alpha-adrenergic receptors therapy producing contraction of the dilator pupillae muscle and produces mydriasis. Tropicamide is a mydriatic and cyclopledic drug. It blocks the parasympathetic fires leading to relaxation of the sphincter pupillae muscle of the iris. This leads to mydriasis. It also blocks the parasympathetic fibres of the cilliary muscles therapy leading to paralysis of accommodation (cycloplegia).

Mydriasis produced by Tropicamide is more rapid but less prolonged than that produced by other mydriatic drugs. The maximum mydriatic effect appears in about 20-40 minutes. Maximum cycloplegia occurs within 20-35 minutes. Mydriasis generally lasts about 6-7 hours and cycloplegia persists for 50 minutes to 6 hours. Since the cycloplegia effect of Tropicamide is least as compared to cyclopentolate, atropine and homatropine it will give minimum side effects, since both these drugs produce mydriasis by separate routes, a combination of these drugs will result in wider and rapid mydriasis. Moreover, it is possible to use lower concentration of each ingredient.