TRAVICOL Caplet

- Pain relief in cases of: headache, toothache, joint pain, muscle pain, traumatic pain, earache, sore throat.

- Febrile symptoms: due to infection, vaccination, colds, flu.

Dosage and Administration

-Orally and before meals 1 hour: Each drink 4-6 hours apart.

- Use as directed by the physician or in the following doses:

- Children from 8-10 years: oral dose of 1 tablet, maximum 4 doses/24 hours.

- Children from 11-16 years: 1-2 tablets/time, maximum 4 doses/24 hours.

Adults and children over the age of 16: 2-3 tablets/day, up to 4g/24hours.

* Note:

- Do not use TRAVICOL 325 for more than 5 days in children because of such prolonged and severe pain that may be a sign of a medical condition that needs to be diagnosed and treated.

- Do not use TRAVICOL 325 for self-treatment of high fever >39.5℃, fever that lasts more than 3 days, as such fever is a sign of a condition that needs to be diagnosed quickly.

- Hypersensitivity to paracetamol or any component of the drug.

- Severe liver failure.

- Serious skin reactions such as Steven-Johnson syndrome, Lyell’s syndrome, acute necrotizing eczema, acute onset of acute redness. In case of appearance of rash or other manifestations of skin, stop taking medicine and see doctor.

- Skin rash and other allergic reactions occasionally occur. Usually it is rash or urticaria, but sometimes it is worse and may be accompanied by fever due to medications and mucosal lesions.

If you have fever, swollen water around the natural cavities, think of Stevens-Johnson syndrome, stop taking it immediately.

Patients susceptible to salicylates are rarely susceptible to paracetamol and related drugs. In a few instances, paracetamol has caused neutropenia, and reduced whole blood.

- High doses and prolonged paracetamol may slightly increase the anticoagulant effect of coumarin and indandion derivatives.

- Need carefully with the possibility of severe hypothermia in patients taking concomitant phenothiazine and hypothermia.

- Long-term drinking may increase the risk of paracetamol toxicity.

- Anticonvulsants (phenyntinoin, barbiturate, carbamazepine, etc): may increase the hepatotoxic toxicity of paracetamol by increasing the conversion of drugs into toxic substances to the liver.

- Colestyramine reduces paracetamol absorption.

- Contraceptives (oral) may increase paracetamol clearance.

- Probenecid can reduce paracetamol clearance and increase plasma half-life of paracetamol.

- Pregnancy: The safety of paracetamol for ADR-related pregnancy has not been established for gestational development. Therefore, paracetamol should only be used when pregnant.

- Lactation: use of paracetamol does not show ADR in nursing infants.

- Serious skin reactions, ability cause die include Steven-Johnson syndrome (SJS), Tainted epidermal necrolysis (TEN), Acute generalized exanthematous syndrome (AGEP), rare but occurring with paracetamol, usually does not depend on the effect of other drugs. Although other analgesics and antipyretics (such as NSAIDs) can cause similar reactions, cross-sensitivity with paracetamol does not occur. Patients should stop taking medicine and see a physician immediately after rash or other manifestations of skin or sensitive reactions during treatment. Patients with a history of such reactions should not take paracetamol.

- Sometimes, there are skin reactions including flatulence, itching and urticaria; Other hypersensitivity reactions including larynx, angioedema, and anaphylactoid reactions may occur less frequently. Thrombocytopenia, thrombocytopenia and total hemoglobinemia have been reported with the use of p-aminophenol derivatives, especially when extended in large doses. Neutropenia and thrombocytopenic purpura have occurred with paracetamol. Rarely, agranulocytosis has been reported with paracetamol.

- Use caution in patients with liver failure, kidney failure, alcoholism, chronic malnutrition or dehydration.

- Paracetamol should be used with caution in patients with pre-existing anemia, as cyanosis may not be evident, despite the high levels of methemoglobin in the blood.

- Drinking a lot of alcohol can increase the toxicity to the liver of paracetamol, so avoid or limit alcohol intake.

- Co-administration with paracetamol-containing preparations may cause poisoning or overdose of paracetamol.

- Paracetamol is an active metabolite of phenacetin, an effective analgesic - antipyretics that can replace aspirin; However, unlike aspirin, paracetamol is not effective in treating inflammation. With equal doses, paracetamol has analgesic and antipyretic action similar to aspirin.

- Paracetamol reduces the body temperature in people with fever, but rarely causes hypothermia in normal people. Drugs affecting the hypothalamus cause hypothermia exacerbated by increased vasodilatation and increased peripheral blood flow.

- Paracetamol, with therapeutic doses, has little effect on the cardiovascular and respiratory systems, does not alter the acid-base balance, does not irritate, scratch or bleed the stomach like salicylate, because paracetamol does not work on systemic cyclooxygenase, only effects on cyclooxygenase/prostaglandin of the central nervous system.

- Paracetamol has no effect on platelets or bleeding time.