QBAL Tablet

Peripheral Neuropathies.

Megaloblastic anemia caused by vitamin B12 deficiency.

Dosage and Administration

The usual adult dosage for oral use is 3 tablets daily in 3 divided doses.

The dosage may be adjusted depending on the patient’s age and symptoms.

Hypersensitivity to mecobalamin or other Vitamin B12 containing products.

In case of tablets, symptoms such as anorexia, nausea or diarrhoea may infrequently occur.

Mecobalamin should not be used for more than 1 month unless it is effective.

Prolonged use of larger doses of mecobalamin is not recommended for patients whose occupation requires handling mercury or its compounds. Since this drug decomposes on exposure to light, it should be used immediately after the package is opened.

1. Mecobalamin is a kind of endogenous coenzyme B12

Mecobalamin plays an important role in transmethylation as a coenzyme of methionine synthetase in the synthesis of methionine from homocysteine.

2. Mecobalamin is well transported to nerve cell organelles, and promotes nucleic acid and protein synthesis.

Mecobalamin is better transported to nerve cell organelles than cyanocobalamin in rats. It has been shown in experiments with cells from the brain origin and spinal nerve cells in mice to be involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folic acid utilization and metabolism of nucleic acid. Also Mecobalamin promotes nucleic acid and protein synthesis in rats more than cobamamide does.

3. Mecobalamin promotes axonal transport and axonal regeneration.

Mecobalamin normalizes axonal skeletal proteins transport in sciatic cells from rat models with streptozotocin induced diabetes mellitus. It exhibits neuropathologically and electrophysiologically inhibitory effects on nerve degeneration in neuropathies induced by drugs, such as adriamycin, acrylamide and vincristine (in rats and rabbits), models of axonal degeneration in mice and neuropathies in rats with spontaneous diabetes mellitus.

4. Mecobalamin promotes myelination (phospholipid synthesis).

Mecobalamin promotes the synthesis of lecithin, the main constituent of medullary sheath lipids, and increases myelination of neurons in rat tissue culture more than cobamamide does.

5. Mecobalamin restores delayed synaptic transmission and diminished neurotransmitters to normal.

Mecobalamin restores end-plate potential induction early by increasing nerve fiber excitability in the crushed sciatic nerve in rats. In addition, Mecobalamin normalized diminished brain tissue levels of acetylcholine in rats fed a choline-deficient diet.