PROSAN Tablet

It is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Dosage and Administration

The usual starting dose is 50mg once daily, with 25mg used in patients with possible depletion of intravascular volume (e.g., patients treated with diuretics) and patients with a history of hepatic impairment. It can be administered once or twice daily with total daily doses ranging from 25mg to 100mg.

Losartan Potassium is contraindicated in patients who are hypersensitive to the active ingredient or any component of the drug.

In clinical trials, dizziness was the only side effect reported that occurred with an incidence greater than placebo in 1% patients treated with Losartan. Rarely, rash was reported, although the incidence in controlled clinical trials was less than placebo. Angioedema, involving swelling of the face, lips and/or tongue, has been reported rarely in patients treated with Losartan. The incidence of cough is similar to placebo and significantly lower than that observed with ACE inhibitors.

No drug interactions of clinical significance have been identified. Compounds that have been studied in clinical pharmacokinetic trials include hydrochlorothiazide, digoxin, warfarin, cimetidine, ketoconazole, and phenobarbital.

Pregnant women

Prosan must be discontinued as soon as possible when pregnancy is detected.

Lactation

It should not be prescribed during lactation, as there is no information in human on the passage of Losartan into breast milk.

Children: There are no data on the safety or efficacy of Prosan in children.

Losartan Potassium is an angiotensin-Ⅱreceptor (type AT1) antagonist. Angiotensin-Ⅱis a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone secreting effects of angiotensin-Ⅱby selectively blocking the binding of angiotensin-Ⅱto the AT1 receptor found in many tissues