PORO Suppository

Indication:

For the symptomatic relief of fever and pain (headache, muscle ache) associated with common cold.

Dosage and administration:

Children 1-2 years: 1 suppository of 125 mg.

Children 2-6 years: 1-2 suppositories of 125 mg

Children 6-12 years: 1-2 suppositories of 250 mg

To be inserted deep into rectum every 4 hours as needed, up to 4 times daily.

Contraindicated in patients who have shown hypersensitivity to paracetamol.

Side effects of paracetamol are usually mild, though haematological reactions have been reported. Skin rashes and other allergic reactions occur occasionally. Cutaneous hypersensitivity reactions including skin rashes, angiodema, Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis have been reported.

1. The half life of chloramphenicol is prolonged by paracetamol.

2. The absorption rate of paracetamol is increased by metaclopramide.

1. Use with caution to patient with renal or hepatic dysfunction.

2. If fever persists for more than 3 days or recurs, or if pain continues for more than 5 days, consult a physician immediately.

3. Allergy alert:

Paracetamol may cause severe skin reactions. Symptoms may include skin reddening, blisters or rash.

These could be signs of a serious conditions. If these reactions occur, stop use and seek medical assistance right away.

1. Paracetamol may act by inhibiting prostaglandin synthesis in the central nervous system and through a peripheral action by blocking pain impulse generation. The peripheral action may also be due to inhibition of the synthesis of prostaglandins which sensitize pain receptors to mechanical or chemical stimulation.

2. Paracetamol produces antipyresis by acting centrally on the hypothalamic heat-regulation center to produce peripheral vasodilation resulting in increase blood flow through the skin, sweating and heat loss. The central action probably involved inhibition of prostaglandin synthesis in the hypothalamus.