NIFELAT R Tablet

For the prophylaxis of angina pectoris and the treatment of all grades of hypertension.

Dosage

The recommended dose is 1 tablet 2 times daily taken with a little water during or after meals. If necessary the dose may be increased 2 tablets 2 times daily.

In patients hypersensitive to Nifedipine. Nifelat R should not be administered to patients with cardiogenic shock.

The most common side-effects are associated with the vasodilatory action, such dizziness, headache, flushing, hypotension and peripheral oedema. A paradoxical increase in ischaemic chest pain may occur at the start of treatment. There have been reports of abnormalities in liver function due to hypersensitivity reactions, and gingival hyperplasia has been reported.

Other less commonly reported side-effects include, rash, nausea, lethargy and increased frequency of micturition.

The antihypertensive effect of Nifelat R may be potentiated by concurrent administration of Cimetidine.

When used in combination with Nifelat R, serum Quinidine levels have been reported to be suppressed.

Pregnancy

Nifelat R is contra-indicated in pregnant women or women who may become pregnant.

Breast-feeding

Nifelat R should not be administered to nursing mothers.

Nifelat R should be used with caution in patients with hypotension and in patients whose cardiac reserve is poor. In patients with severe aortic stenosis Nifelat R may increase the risk of developing heart failure. Nifelat R may enhance the antihypertensive effects of beta-adrenoceptor blocking agents although the combination is generally well tolerated. The use of Nifelat R in diabetic patients may require adjustment of their control. Nifelat R should be discontinued in patients who experience ischaemic pain following its administration.

Nifelat R is a specific and potent calcium antagonist with peripheral and coronary vasodilative properties.

Nifelat R increases coronary blood flow and decreases myocardial oxygen consumption.

Nifelat R has no anti-arrhythmic activity.

Nifelat R does not increase the intra-ocular pressure and can be used in patients with glaucoma.

Nifelat R tablets taken twice daily provide 24 hour control of increased blood pressure. The percentage reduction of blood pressure caused by Nifelat R is directly related to its initial height. Nifelat R does not reduce the blood pressure of normotensive individuals.