NATRILIX SR Tablet

គុណភាពព្យាបាល
ឱសថនេះប្រើសំរាប់ព្យាបាលជម្ងឺសម្ពាធឈាមឡើង។
កំរិតនិងរបៀបប្រើ
・មនុស្សពេញវ័យ៖
- ប្រើម្ដង1គ្រាប់ 1ដងក្នុងមួយថ្ងៃ (លេបពេលអាហារពេលព្រឹក)
- រយៈពេលប្រើ: អនុវត្តតាមវេជ្ជបញ្ជារបស់គ្រូពេទ្យ
・សំគាល់៖
- ក្នុងករណីអ្នកជម្ងឺភ្លេចលេបឱសថនេះ 1ដងឬច្រើនដង ត្រូវពិគ្រោះជាមួយគ្រូពេទ្យ និងមិនត្រូវលេបឱសថនេះជំនួសពេលដែលភ្លេចលេបទេ។
- ក្នុងគ្រប់ករណីអ្នកជម្ងឺត្រូវគោរពតាមវេជ្ជបញ្ជារបស់គ្រូពេទ្យអោយបានត្រឹមត្រូវ។

 

Indication

Indapamide is a diuretic. Most diuretics increase the amount of urine produced by the kidneys. However, indapamide is different from other diurectics, as it only causes a slight increase in the amount of urine produced.

This medicine is intended to reduce high blood pressure (hypertension) in adults.

Dosage

The recommended dose is 1 tablet each day, preferably in the morning. The tablets can be taken irrespective of meals. They should be swallowed whole with water. Do not crush or chew them.

Treatment for high blood pressure is usually life-long.

ហាមប្រើ
- ចំពោះអ្នកជម្ងឺអាល្លែកហ្ស៊ីជាមួយសារធាតុផ្សំណាមួយនៃឱសថនេះ ឬជាមួយពួកឱសថ Sulfamidea។
- ចំពោះអ្នកជម្ងឺខ្សោយតម្រងនោម
- ចំពោះអ្នកជម្ងឺថ្លើមធ្ងន់ធ្ងរ
- ចំពោះអ្នកជម្ងឺមានកំរិតជាតិប៉ូតាស្យូមនៅក្នុងឈាមទាបជាងកំរិតធម្មតា។

 

- If you are allergic to the active substance or any other sulphonamide or to any of the other ingredients of this medicine,

- If you have severe kidney disease,

- If you have severe liver disease or suffer from a condition called hepatic encephalopathy (degenerative disease of the brain),

- If you have low potassium levels in your blood.

ផលរំខានខ្លះៗ៖
- សភាពអស់កម្លាំង វិលមុខនៅពេលក្រោកឈរ ថយចុះកំរិតជាតិទឹក ជាពិសេសចំពោះមនុស្សចាស់និងអ្នកមានជម្ងឺខ្សោយបេះដូង។
- ប្រតិកម្មអាល្លែកហ្ស៊ី ស្បែកឡើងកន្ទួលក្រហម
- កំរិតប៉ូតាស្យូមនៅក្នុងឈាមថយចុះខ្លាំង ជាពិសេសចំពោះមនុស្សចាស់ ឬអ្នកជម្ងឺដែលមានរបបអាហារមិនគ្រប់គ្រាន់។

 

Stop taking this medicinal product and see a doctor immediately, if you experience any of the following side effects:

- Angioedema and/or urticaria. Angioedema is characterized by swelling of the skin of extremities or face, swelling of the lips or tongue, swelling of the mucous membranes of the throat or airways resulting in shortness of breath or difficulty of swallowing. If this occurs, contact your doctor immediately, (Very rare)

- Severe skin reactions including intense skin rash, reddening of the skin over your whole body, severe itching, blistering, peeling and swelling of the skin, inflammation of mucous membranes (Steven Johnson Syndrome) or other allergic reactions, (Very rare)

- Life-threatening irregular beat, (Not known)

- Inflamed pancreas which may cause severe abdominal and back pain accompanied with feeling very unwell, (Very rare)

- Disease of the brain caused by liver illness (hepatic encephalopathy), (Not known)

- Inflammation of the liver (hepatitis), (Not known)

In decreasing order of frequency, other side effects can include:

- Common

- Red raised skin rash,

- Allergic reactions, mainly dermatological, in subjects with a predisposition to allergic and asthmatic reactions.

- Uncommon

- Vomiting,

- Red pinpoints on skin (purpura).

- Rare

- Feeling of tiredness, headache, pins and needles (paresthesia), vertigo,

- Gastro-intestinal disorders (such as nausea, constipation), dry mouth,

- Very rare:

- Changes in blood cells, such as thrombocytopenia (decrease in the number of platelets which causes easy bruising and nasal bleeding), leucopenia (decrease of white blood cells which may cause unexplained fever, soreness of the throat or other flu-like symptoms - if this occurs, contact your doctor) and anaemia (decrease in red blood cells),

- High level of calcium in blood,

- Heart rhythm irregularities, low blood pressure,

- Kidney disease,

- Abnormal hepatic function.

- Not known:

- Fainting,

- If you suffer from systemic lupus erythematous (a type of collagen disease), this might get worse,

- Cases of photosensitivity reactions (change in skin appearance) after exposure to the sun or artificial UVA have also been reported,

- Short sightedness (myopia),

- Blurred vision,

- Visual impairment,

- Changes may occur in your laboratory parameters (blood tests) and your doctor may need to give you blood tests to check your condition. The following changes in laboratory parameters may occur:

 low potassium in the blood,

 low sodium in the blood that may lead to dehydration and low blood pressure,

 increase in uric acid, a substance which may cause or worsen gout (painful joint(s) especially in the feet),

 increase in blood glucose levels in diabetic patients,

 increased levels of liver enzymes.

- Abnormal ECG heart tracing.

ក្នុងពេលប្រើឱសថនេះ ដើម្បីជៀសវាងកើតឡើងនូវប្រតិកម្មរវាងឱសថនេះនិងឱសថផ្សេងដូចជា Lithium ពួកឱសថដែលធ្វើអោយមានវិបត្តិចង្វាក់បេះដូង។ល។ មុនប្រើឱសថនេះ ត្រូវពិគ្រោះជាមួយគ្រូពេទ្យឬឱសថការី។

 

You should not take this medicine with lithium due to the risk or increased levels of lithium in the blood.

Special care may be required:

- medicines used for heart rhythm problems (e.g. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, digitalis),

- medicines used to treat mental disorders such as depression, anxiety, schizophrenia… (e.g. tricyclic antidepressants, antipsychotic drugs, neuroleptics),

- bepridil (used to treat angina pectoris, a condition causing chest pain),

- cisapride, diphemanil (used to treat gastro-intestinal problems),

- sparfloxacin, moxifloxacin, erythromycin by injection (antibiotics used to treat infections),

- vincamine by injection (used to treat symptomatic cognitive disorders in elderly including memory loss),

- halofantrine (antiparasitic drug used to treat certain types of malaria),

- pentamidine (used to treat certain types of pneumonia),

- mizolastine (used to treat allergic reactions, such as hay fever),

- NSAIDs for pain relief (e.g. ibuprofen) or high doses of acetylsalicylic acid,

- ACE inhibitors (used to treat high blood pressure and heart failure),

- amphotericin B by injection (anti-fungal medicines),

- oral corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis,

- stimulant laxatives,

- baclofen (to treat muscle stiffness occurring in diseases such as multiple sclerosis),

- potassium-sparing diuretics (amiloride, spironolactone, triamterene),

- metformin (to treat diabetes),

- iodinated contrast media (used for tests involving X-rays),

- calcium tablets or other calcium supplements,

- ciclosporin, tacrolimus or other medicines to depress the immune system after organ transplantation, to treat autoimmune diseases, or severe rheumatic or dermatological diseases,

- tetracosactide (to treat Crohn’s disease).

ចំពោះស្ត្រីមានផ្ទៃពោះនិងស្ត្រីបំបៅកូនមុនប្រើឱសថនេះ ត្រូវពិគ្រោះជាមួយគ្រូពេទ្យ។

 

This medicine is not recommended during pregnancy. When a pregnancy is planned or confirmed, the switch to an alternative treatment should be initiated as soon as possible. Please tell your doctor if you are pregnant or wish to become pregnant.

The active ingredient is excreted in milk. Breastfeeding is not advisable if you are taking this medicine.

ការប្រុងប្រយ័ត្ន៖
- ត្រូវប្រើឱសថនេះដោយប្រុងប្រយ័ត្នក្នុងករណីមានវិបត្តិលំនឹងនៃអេឡិចត្រូលីត ជម្ងឺទឹកនោមផ្អែម ជម្ងឺប្រគ្រីវ វិបត្តិតំរងនោម
- ក្នុងពេលប្រើឱសថនេះ អ្នកជម្ងឺត្រូវពិនិត្យឈាមដោយមន្ទីរពិសោធន៍អោយបានត្រឹមត្រូវតាមវេជ្ជបញ្ជារបស់គ្រូពេទ្យ
- ត្រូវបញ្ឈប់ការប្រើប្រាស់ឱសថនេះនៅពេលមានកើតឡើងនូវជម្ងឺថ្លើម។
- គួរជៀសវាងប្រើឱសថនេះក្នុងពេលបញ្ជាយានយន្តឬគ្រឿងម៉ាស៊ីន។
- ចំពោះកីឡាករត្រូវប្រុងប្រយ័ត្ន ក្នុងពេលប្រើឱសថនេះអាចបណ្ដាលអោយលទ្ធផលតេស្តរកសារធាតុ antidopa វិជ្ជមានដោយសារធាតុផ្សំនៃឱសថនេះ។

 

Talk to your doctor or pharmacist before taking NTRILIX SR:

- if you have liver problems,

- if you have diabetes,

- if you suffer from gout,

- if you have any heart rhythm problems or problems with your kidneys,

- if you need to have a test to check how well your parathyroid gland is working.

You should tell your doctor if you had photosensitivity reactions.

Your doctor may give you blood tests to check for low sodium or potassium levels or high calcium levels.

Athletes should be aware that this medicine contains an active ingredient, which may give a positive reaction in doping tests.

Indapamide is a diuretic. Most diuretics increase the amount of urine produced by the kidneys. However, indapamide is different from other diuretics, as it only causes a slight increase in the amount of urine produced.

This medicine is intended to reduce high blood pressure (hypertension) in adults.