METHYCOBAL Tablet

គុណភាពព្យាបាល
ជម្ងឺឈឺចាប់ទាក់ទងនឹងប្រព័ន្ធសរសៃប្រសាទក្រៅ (Peripheral neuropathies)។
កំរិតនិងរបៀបប្រើ
មនុស្សពេញវ័យ៖ លេបម្ដង 1គ្រាប់ 3ដង ក្នុង1ថ្ងៃ កំរិតប្រើត្រូវអោយសមស្របតាមអាយុ និងសភាពធ្ងន់ធ្ងរនៃរោគសញ្ញា។

Peripheral neuropathies

Dosage and administration

Adults: 1 tablet 3 times a day.

The dosage should be adjusted according to age and severity of symptoms.

ហាមប្រើចំពោះអ្នកជម្ងឺមានប្រវត្តិងាយប្រតិកម្មជាមួយឱសថនេះ។

ផលរំខានខ្លះៗ
បាត់បង់ការឃ្លាន ចង្អោរ រាក ឬ រោគសញ្ញាក្រពះពោះវៀនដទៃទៀត អាចកើតមាន។

Side effects
Adverse reactions were reported in 146 of 15.180 patients (0.96%). (At the end of the investigation for incidence of adverse reactions)
- Gastrointestinal: Anorexia, nausea/vomiting and diarrhea (5% > ≥0.1%)
- Hypersensitivity: Rash (<0.1%)

ការប្រុងប្រយ័ត្ន៖
- មិនត្រូវប្រើរយៈពេលយូរខែទេ ប្រសិនបើសភាពជម្ងឺមិនធូរស្រាល។

1. METHYCOBAL should not be used aimlessly for more than one month unless it is effective.

2. The prolonged use of larger doses of METHYCOBAL is not recommended for patients whose occupation requires the handling of mercury or mercury compounds.

Biochemically, mecobalamin is concerned with transmethylation as a vitamin B12 containing coenzyme occurring in the blood.

1. Mecobalamin is a king of endogenous coenzyme B12

Mecobalamin plays an important role in transmethylation as a coenzyme of methionine synthetase in the synthesis of methionine from homocysteine.

2. Mecobalamin is well transported to nerve cell organelles, and promotes nucleic acid and protein synthesis.

Mecobalamin is better transported to nerve all organelles than cyanocobalamin in rats. It has been shown in experiments with cells from the brain origin and spinal nerve cells in rats to be involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folic acid utilization and metabolism of nucleic acid. Also, mecobalamin promotes nucleic acid and protein synthesis in rats more than cobamamide does.

3. Mecobalamin promotes axonal transport and axonal regeneration.

Mecobalamin normalizes axonal skeletal protein transport in sciatic nerve cells from rat models with streptozotocin-induced diabetes mellitus. It exhibits neuropathologically and electrophysiologically inhibitory effects on nerve degeneration in neuropathies induced by drugs, such as adriamycin, acrylamide, and vincristine (in rats and rabbits), models of axonal degeneration in mice and neuropathies in rats with spontaneous diabetes mellitus.

4. Mecobalamin promotes myelination (phospholipid synthesis).

Mecobalamin promotes the synthesis of lecithin, the main constituent of medullary sheath lipids, and increases myelination of neurons in rat tissue culture more than cobamamide does.

5. Mecobalamin restores delayed synaptic transmission and diminished neurotransmitters to normal.