LEVOAS-500 Tablet

Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.

In adults with infections of mild or moderate severity, Levofloxacin are indicated for the treatment of the following infections:

- Acute bacterial sinusitis

- Acute bacterial exacerbations of chronic bronchitis

- Community-acquired pneumonia

- Complicated urinary tract infections including pyelonephritis chronic bacterial prostatitis

- Skin and soft tissue infections

- Culture and susceptibility testing

- Inhalation anthrax

- Uncomplicated cystitis

Uncomplicated Skin and Structure Infections.

Dosage and administration

Route of Administration: Oral

For adults: 1 tablet once daily or as directed by the physician.

- In patients hypersensitive to Levofloxacin or other Quinolones or any of the excipients

- In patients with epilepsy

- In patients with history of tendon disorders related to Fluoroquinolone administration

- In children or growing adolescents

- During pregnancy

- In breast-feeding women.

Common: Headache, Dizziness, Insomnia, Diarrhoea, Vomiting, Nausea.

Uncommon: Fungal infection including Candida infection, Eosinophilia, Anxiety, Confusional state, Nervousness, Somnolence, Tremor, Abdominal pain, Constipation, Rash.

Rare: Depression, Agitation, Nightmares, Tachycardia, Palpitation.

Antacids, Sucralfate, Metal Cations, Multivitamins

Theophylline

Warfarin

Cyclosporine

Digoxin

Probenecid and Cimetidine

NSAIDs

Antidiabetic agents.

Contraindicated.

See the package insert about the details.

- Fluoroquinolones, including levofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.

- Fluoroquinolones, including Levofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid Levofloxacin in patients with a known history of myasthenia gravis.

- Serious and occasionally fatal hypersensitivity and/or anaphylactic reactions have been reported in patients receiving therapy with Quinolones, including levofloxacin. These reactions often occur following the first dose.

- Prescribing Levofloxacin in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development or drug-resistant bacteria.

- Although Levofloxacin is more soluble than other Quinolones, adequate hydration of patients receiving Levofloxacin should be maintained to prevent the formation of highly concentrated urine.

- Administer Levofloxacin with caution in the presence of renal insufficiency.

- As with other Quinolones, disturbances of blood glucose, including symptomatic hyper-and hypoglycemia, have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g. glyburide, glibenclamide) or with insulin.

Levofloxacin inhibits bacterial typeⅡtopoisomerases, topoisomeraseⅣand DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.