LEONAZ Tablet

In persons with a history of hypersensitivity to Levofloxacin, quinolone antimicrobial agents or any other components of this product.

Flatulence, Dizziness, Diarrhoea, Anxiety, Restlessness, Constipation, Abdominal pain, Confusion, Pruritus, Hallucination, Dyspepsia, Depression, Nightmares

See the package insert about the details.

Cyclosporin A, Theophylline, Warfarin.

See the package insert about the derails.

Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture. This risk is further increased in those over age 60, in kidney, heart, and lung transplant recipients and with use of concomitant steroid therapy. Physicians should advise patients, at the first sign of tendon pain, swelling, or inflammation, to stop taking the fluoroquinolone, to avoid exercise and use of the affected area, and to promptly contact their doctor about changing to a non-fluoroquinolone antimicrobial drug.

Selection of a fluoroquinolone for the treatment or prevention of an infection should be limited to those conditions that are proven or strongly suspected to be caused by bacteria.

The safety and efficacy of Levofloxacin in pediatric patients, adolescents (under the age of 18 years), pregnant women, and nursing women have not been established. There is a risk of serious and occasionally fatal hypersensitivity reactions after multiple doses. Treatment should be discontinued at the first appearance of skin rash, jaundice or any other sign of hypersensitivity and supportive measures should be instituted.

Risk of clostridium difficile-associated diarrhoea (CDAD) should be considered.

Precautions

Administer Levofloxacin with caution in the presence of renal insufficiency. Careful clinical observation and appropriate laboratory studies should be performed prior to and during therapy since elimination of levofloxacin may be reduced.

In patients with impaired renal function (creatinine clearance <50mL/min), adjustment of the dosage regimen is necessary to avoid the accumulation of Levofloxacin due to decreased clearance.