LAZ Capsule

Hypersensitivity to lansoprazole

- During the clinical study, side effects are diarrhea, headache, dizziness, skin rashes and respiratory tract symptoms may occur.

- Increases temporary in liver enzyme value, haematocrit, haemoglobin concentration, protein urinary excretion and uric acid.

- Abdominal pain, dyspepsia, vomiting, nausea, flatulence, constipation, dry mouth, fatigue and headache.

- A few cases arthralgia, peripheral oedema, depression may occur.

- Haematological changes, like thrombocytopenia, eosinophilia and leucopenia have been reported rarely.

- Benzimidazole compound such as lansoprazole and omeprazole partially inhibit the oxidative metabolism of drugs metabolized by cytochrom metabolism P450 enzume subfamily IIC, such as diazepam. But lansoprazole interactive minimum than omeprazole.

- There is no clinical studies report between lansoprazole with diazepam, propanolol, warfarine, prednison (or prednisolone), phenitoin, or thophyllin.

- Pharmacokinetic studies showed lansoprazole administered with the combined oral contraceptive like ethinylestradiol/levonorgestrel to have no effect on Cmax or AUC values of contraceptive under "steady state" conditions or on levels of endogenous hormones.

- During therapy with lansoprazole. malabsorption of cyanocobalamin may occur.

- Antacids and sucralfate may be reduce the bioavailability of lansoprazole therefore not be taken 1 hour before lansoprazole administration.

Breast feeding should be discontinued the use of lansoprazole is considered essential.

- There is insufficient evidence to recommend the use of Lansoprazole in pregnancy.

- Like other anti ulcer treatment, possibility of benign should be diminished if gastric ulcer is suspected, because Lansoprazole can alleviate symptoms and diagnosis delayed.

- Breast feeding should be discontinued the use of Lansoprazole is considered essential.

Lansoprazole, a substituted benzimidazole derivative is an acid pump inhibitor that effectively decreases gastric acid. Lansoprazole is converted in the acidic environment of the canaliculi of the gastric parietal cell to active sulfonamide derivatives which bind to the sulphydryl group of H+/K+-ATPase and producing inhibition of both neutrally and peripherally.