FLAGYL Tablet

To treat certain infections caused by bacteria or parasite that are sensitive to Flagyl.

Dosage&Administration

For adults and children at least 6 years of age only.

The dosage depends on your age and the illness being treated.

The usual dose is:

- Adults: 0.5-1.5g/day

- Children: 375mg/day - 20-40mg/kg/day

In some cases, it is essential that your partner be treated, whether or not he/she has any clinical signs.

Oral route.

Swallow the tablets with water.

2-3 times a day, depending on the infection being treated.

In order to be effective, this antibiotic must be taken regularly at the prescribed doses and for as long as your doctor advises.

If your fever or any other symptom disappears, it does not mean that you are cured.

If you feel tired, this is not due to the antibiotic treatment but to the infection itself. Reducing or stopping your treatment would have no effect on this feeling and would only delay your recovery.

Special cases: treatment of giardiasis should last 5 days, treatment of amoebiasis and some types of vaginitis, 7 days and treatment of trichomoniasis, 10days.

- if you are allergic to metronidazole, to any medicine in the imidazole group or to any other ingredient of this medicine.

- if you are allergic (hypersensitive) to wheat, as this medicine contains wheat starch (gluten).

- if the patient is a child under 6 years of age.

Digestive disorders

- digestive disorders that are not serious, such as stomach pains, nausea, vomiting, diarrhea,

- inflammation of the tongue and dry mouth,

- inflammation of the mouth, taste disorders, loss of appetite,

- pancreatitis, which is reversible after stopping treatment,

- discoloration of change in the appearance of the tongue.

Effects on the skin and mucous membranes

- hot flushes with redness of the face, itching, skin rashes sometimes accompanied by fever,

- hives (skin rash similar to nettle rash), sudden allergic swelling of the face and neck (angio-edema), allergic shock which could be life-threatening,

- very rare cases of redness spreading to the whole body with pustules, accompanied by fever (acute generalized exanthematous pustulosis),

-a blistering rash with peeling of the skin which can rapidly spread to the whole body and be life-threatening (toxic epidermal necrolysis, Stevens-Johnson syndrome).

Nervous system disorders

- nerve damage in the limbs (peripheral sensory neuropathy) with effects on the hands and feet such as tingling, pricking, feeling cold, numbness and reduced sense of touch,

- headache,

- dizziness,

- seizures,

- confusion,

- neurological disorders, known as encephalopathy or cerebellar syndrome, with symptoms including confusion, consciousness disorders, behavioral disorders, difficulty coordinating movements, pronunciation disorders, gait disorders, involuntary eye movements, shakiness. These disorders are generally reversible on treatment discontinuation and may be associated with changes in MRI scans. Very rare cases of fatal outcome have been reported.

- non-bacterial meningitis.

Mental disorders

- hallucinations,

- personality disorders (paranoia, delusion) possibly with suicidal ideas or attempts,

- depressive tendencies.

Vision disorders

- temporary vision disorders such as blurred vision, double vision, short-sightedness, decreased vision, changes in color vision,

- optic nerve damage/inflammation.

Blood disorders

- abnormally low platelet counts, abnormally low or major drop in the number of certain white blood cells (neutrophils).

Effects on the liver

- elevated liver enzymes (transaminases, alkaline phosphatase),

- very rare cases of serious liver disease (sometimes accompanied by jaundice), in particular cases of liver failure requiring a transplant.

Other effects

- reddish-brown colored urine caused by the medicine.

Tell your doctor if you are taking:

- medicines containing alcohol because of the risk of side effects such as redness of the face, feeling hot, vomiting and increased heart rate.

- busulfan,

- disulfiram.

Drinking alcoholic beverages should be avoided during treatment because of the risk of side effects such as redness of the face, feeling hot, vomiting and increased heart rate.

If necessary, this medicine may be taken during pregnancy.

You should avoid breast-feeding while taking this medicine.

If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Before taking Flagyl, tell your doctor if you have:

- neurological disorders,

- psychiatric disorders,

- blood disorders,

- ever had meningitis under metronidazole treatment.

Tell your doctor immediately if any of the following problems occur during treatment with Flagyl:

From the first dose, there is a risk of severe and sudden allergic reaction (anaphylactic shock, angioedema) possibly causing the following symptoms: tight chest, dizziness, nausea or fainting, or dizziness when standing up. If these symptoms occur, stop taking this medicine because your life might be in danger and immediately contact a doctor.

If, at the start of treatment, you experience redness all over the body and pustules, accompanied by fever, a serious reaction known as acute generalized exanthematous pustulosis should be suspected, inform your doctor immediately as treatment must be stopped. Any further administration of metronidazole alone or in combination with another active substance in the same medicine is contraindicated if such a reaction occurs.

You should watch out for any signs or potential aggravation of nervous disorders such as difficulty coordinating movements, confusion, seizures, difficulty coordinating movements, confusion, seizures, difficulty speaking or walking, shakiness, involuntary eye movements, as well as other effects on the hands and feet such as tingling, pricking, feeling clod, numbness and reduced sense of touch. These disorders are generally reversible on treatment discontinuation. It is therefore important to stop taking this medicine and see a doctor immediately.

From the very first doses of treatment, your behavior may alter and put you at risk, especially if you have had psychiatric problems in the past. if this happens, you should stop taking the medicine and see a doctor.

If you have had blood disorders in the past or received high-dose and/or long-term treatment, your doctor may prescribe regular blood tests to check your complete blood count.

Inform the doctor or analysis laboratory that you are taking this medicine if you have to have a medical laboratory test; taking metronidazole may interfere with on some laboratory test results (test for Treponema), by triggering a false positive result for a test (Nelson test).

Flagyl is an antibacterial and antiparasitic antibiotic belonging to the 5-nitroimidazole group of medicines.