FEXONA Tablet

It is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.

DOSAGE AND ADMINISTRAION

Adults:

Allergic rhinitis: 120mg once daily or 60mg twice daily.

Urticaria: 180mg once daily.

Children:

2-11 years: 30mg (1 spoonful) or 5ml twice daily.

6 months- 2 years: 15mg (1/2 spoonful) or 2.5ml twice daily.

In patients with a known hypersensitivity to Fexofenadine or any of its ingredients.

Fexofenadine is generally well tolerated. The most commonly reported adverse events are headache, drowsiness, nausea, and dizziness. The incidence of these events observed with Fexofenadine hydrochloride was similar to that observed with placebo.

In pregnancy

Pregnancy Category B. There are no adequate and well controlled studies in pregnant women. Fexofenadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation

It is not known if Fexofenadine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Fexofenadine is administered to a nursing woman.

Studies in the elderly, patients with hepatic impairment and patients with cardiac disease exposed to Fexofenadine showed no statistically significant differences compared to healthy individuals. As with most new drugs there is only limited data in the elderly and renally or hepatically impaired patients. Fexofenadine hydrochloride should be administered with care in these special groups.

Fexofenadine is a second-generation, long lasting H1-receptor antagonist which has a selective and peripheral H1-antagonistic action. Fexofenadine blocks the H1-receptor and thus prevents activation of cells by histamine in the GI fact, large blood vessels and bronchial smooth muscle. This leads to relief of the allergic symptoms. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential, since it does not block the potassium channel involved in repolarization of cardiac cells.