CLAROCIN Tablet

Clarithromycin is contraindicated in patients with a known hypersensitivity to Clarithromycin, erythromycin, or any of the macrolide antibiotics.

Concomitant administration of clarithromycin and any of the following drug is contraindicated: cisapride, pimozide, astemizole, terfenadine and ergotamine or dihydroergotamine.

Pregnancy:

Teratogenic Effects. Pregnancy Category C

There are no adequate and well-controlled studies in pregnant women. Clarithromycin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing mother:

Caution should be exercised when Clarithromycin is administered to a nursing woman. It is known that Clarithromycin is excreted in the milk of lactating animals and that other drugs of this class are excreted in human milk.

Clarithromycin prevents bacteria from growing, by interfering with their protein synthesis. Clarithromycin binds to the subunit 50s of the bacterial ribosome, and thus inhibits the translocation of peptides, resulting in inhibition of protein synthesis.