CLAMOXYL Powder for suspension

- indicated for the treatment of infections caused by sensitive bacteria

- indicated in adults, for the treatment of certain gastric or duodenal ulcers.

Dosage

Dosage varies depending on the disease being treated.

- For adults: from 1g to 6g per 24 hours

-For children: from 25mg/kg to 150mg/kg per 24 hours.

Particular case of some tonsillitis's treatment:

-For adults: 2g twice a day

-For children over 30 months of age: 50mg/kg/day twice a day, during 6 days

The does should be adjusted in the case of renal impairment

Oral use

This medicine can be taken at any time, before, during or after meals

Generally two to three does per day

- Allergy to antibacterial agents from betalactam antibiotic family (penicillins or cephalosporins ) or to the other ingredients.

- Phenylketonuria (hereditary disease detected at birth), due to the presence of aspartam.

This medicine should not generally be used in combination with methotrexate (an immunosuppressant)

Side effects

Uncommon:

-nausea, diarrhoea,

- skin eruption,

- Mucocutaneous candidiasis (infection due to certain microscopic fungi).

Very uncommon:

- vomiting,

- urticaria, itching

Very rare:

-leukopenia (more or less marked decrease in white blood cells), neutropenia (decrease in white blood cells: neutrophils), agranulocytosis (marked decrease in agranulocytosis), thrombocytopenia (decrease in platelets), reversible haemolytic anaemia (red blood cells destruction),

- severe allergic reactions, including angioneurotic oedema, anaphylaxis, serum disease (skin eruption with fever and articulation pains) and hypersensitivity vasculitis (inflammation of smallest vessels) ,

- convulsions,

- pseudomembranous colitis (intestine inflammation with diarrhoea and/or abdominal pains), haemorrhagic colitis (intestine inflammation with diarrhoea and/or bleeding),

- hepatitis (liver inflammation), jaundice,

- skin reactions such as multiform erythema, Stevens-Johnson syndrome, Lyell syndrome (toxic epidermal necrolysis), bullous and exfoliative dermatitis (skin inflammation with bullous),

- acute generalized exanthematous pustulosis (red blotch generalized to the entire body with pustule followed by fever).

Unknown frequency

- allergies of varying severity: Quincke’s oedema (sudden swelling of the face or the neck), respiratory distress, urticaria,

- eosinophilia (rise of certain white blood cells),

- superficial dental coloration reported in children with oral suspension, generally reversible after teeth brushing,

- dizziness,

- interstitial nephritis (inflammation of the kidney), crystalluria (crystal found in urine),

- a moderate and passing rise in AST and/r ALT.

Methotrexate

Pregnancy

If necessary, this medicine can be taken during pregnancy.

Breastfeeding

Breast-feeding is possible while taking this medicine. If the baby suffers problems such as diarrhea, skin rash, candidiasis (infection caused by certain microscopic fungi),inform your doctor immediately.

Inform your doctor in the case of known renal impairment.

Drink plentiful amounts of liquid during treatment.

This medicine can falsify certain test results : Coombs test, blood sugar and total serum proteins, test for glucose in the urine. Inform your doctor that you are taking amoxicillin if these tests are prescribed for you.

Convulsions may occur in patients with impaired renal function, in those receiving high doses or in patient with history of convulsion, treated for epilepsy or with brain disease.

Patient under strict sodium restrictive diet must be informed that this medicine contains 5mg of sodium per measuring spoon.

Beta-lactam group of antibiotics