ASMOFLOX-OZ Tablet

This medicine is primarily indicated in conditions like Mixed diarrheas Postoperative infections, Lower respiratory tract, Lung abscess/emphysema, Bronchiectasis, Upper respiratory tract, Chronic sinusitis, Purulent sinusitis, abcess, Appendicitis, All abscesses, Biliary infections, Osteomyelitis, Wound infections, Postoperative, Infected decubitus ulcer, Immunocompromised patients, Infections in cancer patients, Gynecological infections, Dental infections, Diabetic foot infections.

Dosage and administration

Method of administration: Oral

The usual adult dose is 1 tablet twice a day. The doses may be increased in severe infections. The duration of treatment depends upon the type and severity of infection.

Ofloxacin is now considered to be contraindicated for the treatment of certain sexually transmitted diseases by some experts due to bacterial resistance. The excretion of Ofloxacin may be reduced in patients with severe liver function disorders (e.g. cirrhosis with or without ascites).

Ornidazole contraindicated to agent which shown hypersensitivity to Ornidazole or to other nitroimidazole derivatives.

Digestive and liver side effects: Nausea and vomiting, diarrhoea, abdominal pain, gastric symptoms. Loss of appetite, increase in liver enzymes and/or bilirubin.

Central nervous system: Headache, dizziness, sleep disorders, restlessness.

Extra pyramidal symptoms: Convulsions, hearing disorders (including, in exceptional cases, loss of hearing).

Cardiovascular system: Tachycardia and a temporary decrease in blood pressure have been reported. Circulatory collapse (due to pronounced drop in blood pressure).

Renal side effects: Disturbances of kidney function.

Allergic and skin side effects: Skin rash, itching. Rash on exposure to strong sunlight, other severe skin reactions & hypersensitivity.

Other side effects: Malaise, Excessive rise or fall in blood-sugar levels. Weakness, joint and muscle pains (in isolated cases these may be symptoms of rhabdomyolysis). Tendon discomfort including inflammation and rupture of tendons (e.g. the Achilles tendon) particularly in patients treated concurrently with corticosteroids.

This medicine has not been shown to have any teratogenic effects. In lactating females, a single oral 200mg of dose of Ofloxacin resulted in concentrations of Ofloxacin in milk that were similar to those found in plasma. Because of the potential for serious adverse reactions from Ofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Ofloxacin & Ornidazole must be used with caution in those with known or suspected CNS disorder that may predispose to seizures or lower the seizure threshold (e.g. severe cerebral arteriosclerosis, epilepsy) or in the presence of other risk factors that may predispose to seizures. In renal dysfunction, and in that hypersensitivity to quinolones, must be advocated with caution in hepatic dysfunction.

Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class consider being a second generation fluoroquinolone. Ofloxacin is a broad spectrum antibiotic that is active against both gram-positive and gram-negative bacteria. It functions by inhibiting DNA gyrase, typeⅡtopoisomerase and topoisomeraseⅣ, which is an enzyme necessary to separate (mostly in prokaryotes, in bacteria in particular) n replicate DNA, thereby inhibiting bacterial cell division.

Ornidazole is drug that cures some protozoan infections.