AMLOTRUST Tablet

គុណភាពព្យាបាល៖

- ឱសថនេះប្រើសម្រាប់ជំងឺសម្ពាធឈាមឡើង ជំងឺចុកទ្រូងរ៉ាំរ៉ៃ ជំងឺចុកទ្រូងដោយសារស្ទះសរសៃឈាម

- ឱសថនេះអាចប្រើតែឯង ឬប្រើរួមផ្សំជាមួយឱសថប្រឆាំងជំងឺសម្ពាធឈាមឡើង ឬចុកទ្រូងផ្សេងទៀត។

កម្រិត និងរបៀបប្រើ៖

ចំពោះជំងឺសម្ពាធឈាមឡើង និងជំងឺចុកទ្រូង៖

- កម្រិតប្រើដំបូង 5ម.ក្រ​ លេប ១ដង ១គ្រាប់ក្នុង១ថ្ងៃ។

- បន្ទាប់មកបង្កើនដល់ ១០ម.ក្រទៅតាមស្ថានភាពអ្នកជំងឺក្រោយពេលប្រើបានរយៈពេល ១០ ទៅ ១៤ថ្ងៃ។

For hypertension, chronic stable angina and vasospastic angina (Prinzmetal’s or variant angina), as monotherapy or in combination with other antihypertensive or antianginal drugs.

Dosage and Administration

Adults:

Hypertension: Initial dose is 5mg once daily with a maximum dose of 10mg once daily. Small, fragile, or elderly individuals, or patients with hepatic insufficiency may be started on 2.5mg once daily and this dose may be used when adding Amlotrust to other antihypertensive therapy.

Chronic Stable or Vasospastic Angina: recommended dose is 5-10mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Most patients will require 10mg or for adequate effect.

Coronary Artery Disease: recommended dose range is 5-10mg once daily. In clinical studies the majority of patients required 10mg.

Children:

The effective antihypertensive oral dose in children ages 6-17 years is 2.5-5mg once daily. Doses in excess of 5mg daily have not been studied.

ចំពោះអ្នកធ្លាប់ងាយមានប្រតិកម្មជាមួយឱសថនេះ។

Known hypersensitivity to Amlodipine.

ការប្រើឱសថនេះបណ្តាលឱ្យ៖

ឈឺក្បាល ហើម ហេវហត់ ងងុយដេក ចង្អោរ ឈឺពោះ flushing ញ័រទ្រូង និងវិលមុខ ផលរំខានមិនញឹកញាប់មាន៖ រមាស់ រោលក្រហម ថប់ដង្ហើម អស់កម្លាំង ឈឺសាច់ដុំ វិបត្តិរំលាយអាហារ និងចុកទ្រូង។

Side effects include headache, edema, dizziness, flushing, palpitations, fatigue, somnolence, nausea, and abdominal pain. Less commonly observed side effects are: pruritus, rash, dyspnea, asthenia, muscle cramps and dyspepsia.

ឱសថនេះគ្មានប្រសិទ្ធភាពលើប្រូតេអ៊ីនដែលចាប់យកពួកឱសថ Digoxin, Phenytoin, Warfarin និង Indomethacin ទេ។

In clinical trials, Amlodipine has been safely administered with thiazide diuretics, beta-blockers, ACE-inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, NSAIDs, antibiotics, atorvastatin and oral hypoglycemic drugs.

ចំពោះស្រ្តីមានផ្ទៃពោះ និងស្ត្រីបំបៅកូន និងកុមារមុនប្រើឱសថនេះ ត្រូវពិគ្រោះជាមួយគ្រូពេទ្យ។

Pregnancy

Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.

Nursing Mothers

It is not known whether Amlodipine is excreted in human milk. Hence it is recommended that nursing be discontinued while Amlodipine is administered.

ការប្រុងប្រយ័ត្ន៖

- ចំពោះអ្នកជំងឺស្ទះសរសៃធ្ងន់ធ្ងរ (Aortic stenosis) ការធ្វើលំហាត់ប្រាណនៅពេលប្រើឱសថនេះត្រូវប្រុងប្រយ័ត្ន

- ចំពោះអ្នកជំងឺមានសម្ពាធឈាមចុះ

- ចំពោះអ្នកជំងឺខ្សោយមុខងារថ្លើម

- ចំពោះមនុស្សចាស់ត្រូវប្រើឱសថនេះផ្តើមពីកម្រិតទាប

- ចំពោះអ្នកជំងឺខ្សោយតម្រងនោម

- ចំពោះស្ត្រីមានផ្ទៃពោះ ស្ត្រីបំបៅកូន និងកុមារមុនប្រើ​ឱសថនេះត្រូវពិគ្រោះជាមួយគ្រូពេទ្យ

Rarely, patients with severe obstructive CAD, have developed increased frequency, duration and/or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage increase.

Since the vasodilation induced by Amlodipine is gradual in onset, acute hypotension has rarely been reported after oral administration. Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering Amlodipine, particularly in patients with severe aortic stenosis.

Congestive Heart Failure: Use with caution in patients with CHF.

Hepatic Failure: Since Amlodipine is extensively metabolized by the liver and the plasma elimination half-life is 56 hours, caution should be exercised when administering Amlodipine in patients with impaired hepatic function.

Amlodipine ជាប្រភេទឱសថទប់ស្កាត់អ៊ីយ៉ុងកាល់ស្យូមកុំឱ្យជ្រាបចូលក្នុងសាច់ដុំបេះដូង និងសាច់ដុំរលោង។ សកម្មភាពរបស់ឱសថនេះគឺ ធ្វើឱ្យសរសៃ ឬសាច់ដុំរលោង រលារ (Relaxant) ។

Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions onto these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells.

Serum calcium concentration however is not affected by amlodipine.

Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

The precise mechanisms by which amlodipine relieves angina have not been fully defined, but are thought to include the following:

Exertional Angina: amlodipine has been demonstrated to block constriction and restore blood flow in coronary arteries. This action is responsible for the effectiveness of Amlodipine in vasospastic (Prinzmetal’s or variant) angina.