AMDOCAL PLUS Tablet

ក្រុមហ៊ុនផលិតឱសថ:

 

BEXIMCO PHARMACEUTICALS LTD., Bangladesh

  • សារធាតុសកម្ម
  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់
  • ហាមប្រើ
  • ផលរំខាន
  • អន្តរប្រតិកម្ម
  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន
  • ការប្រុងប្រយ័ត្នជាពិសេស
  • សកម្មភាពឱសថ
  • បរិយាយប័ណ្ណឱសថ 
  • សារធាតុសកម្ម

    1. AMDOCAL PLUS 25 Tablet:

    Amloidpine 5mg, Atenolol 25mg

    2. AMDOCAL PLUS 50 Tablet:

    Amloidpine 5mg, Atenolol 50mg

  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់

    - Hypertension not controlled by monotherapy.

    - Angina pectoris & hypertension co-existing diseases.

    - Post M.I patients.

    - Refractory angina pectoris where nitrate therapy has failed.

    Dosage and Administration

    The recommended dosage is 1 tablet. Depending upon the therapeutic response, titration of the dosage is recommended.

    In elderly patients, it is advisable to initiate the therapy with 1/2 tablet of fixed dose combination of Amlodipine & Atenolol i.e. 25mg Amlodipine & 25mg Atenolol.

  • ហាមប្រើ

    Amlodipine is contraindicated in patients with a known sensitivity to dihydropyridines. It should not be used in cardiogenic shock, clinically significant aortic stenosis, unstable angina (excluding Prinzmetal’s angina).

    Atenolol is contraindicate with a known hypersensitivity to Atenolol, severe bradycardia, second degree or the tired degree heart block, uncontrolled heart failure, hypotension, severe peripheral vascular disease (including intermittent claudication), sick sinus syndrome, cardiogenic shock, phaeochromocytoma (without a concomitant alpha blocker), metabolic acidosis.

  • ផលរំខាន

    Amlodipine: Peripheral edema may occasionally be present but is fully reversible. As with other calcium channel blockers peripheral edema and skin erythema occur in a proportion of patients and facial flushing occurs in 2-5% of patients. Complaints of fatigue were also reported more frequently than in placebo-treated patients. There is evidence that these effects are more common in patients treated with doses greater than 10mg daily.

    Atenolol: Pronounced fatigue and cold extremities have been observed in 10 to 20% of the treated subjects. Complaints about bradycardia, dizziness and gastrointestinal symptoms are less frequent. Despite its relative selectivity, Atenolol can cause bronchospasms in asthma patients.

    Amongst the many but rarely observed side-effects are sleep disturbances, depressions, paresthesiae, impotence, exanthema, psoriasis exacerbations and arthropathies. Clinically relevant changes in the blood sugar have hardly occurred. There is no clarity as to the practical significance of the above mentioned changes in the lipid metabolism.

  • អន្តរប្រតិកម្ម

    Amlodipine: No significant drug interactions.

    Atenolol: The effects of other myocardial depressant agents, including anti-arrhythmics such as Quinidine, Procainamide, or Lignocaine, Phenytoin, and medicines which interfere with calcium transport, such as Verapamil, may also be enhanced by Atenolol.

    The effects of Atenolol are diminished by beta-adrenoceptor stimulating agents such as Isoprenaline; the hypotensive effects of Atenolol may be dangerously reversed and the peripheral vasoconstrictor effects enhanced by alpha-adrenoceptor stimulating agents such as noradrenaline or those with mixed alpha- and beta-adrenoceptor stimulating properties such as adrenaline; bradycardia may also occur.

    The effects of Atenolol may be enhanced by adrenergic neuron blocking agents such as Guanethidine or Bethanidine, or Catecholamine-depleting agents such as Reserpine and the hypotensive effects by diuretics. Atenolol may enhance some of the cardiac effects of digitalis and diminish others. It has been suggested that clonidine withdrawal symptoms may be exacerbated in patients who are concurrently taking a beta blocker.

  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន

    Atenolol crosses the placenta. So it is contraindicated in pregnancy and lactation.

  • ការប្រុងប្រយ័ត្នជាពិសេស

    Atenolol may mask the symptoms of hyperthyroidism. It may also mask the symptoms of hypoglycaemia, as well as enhancing the effects of hypoglycemic agents in patients with diabetes mellitus.

  • សកម្មភាពឱសថ

    Amlodipine Besilate is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine acts directly on vessels to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

    Atenolol is (2-Hydroxy-3-isopropyl-aminopropoxy) phenylacetamide, a selective beta-1 blocker. Beta blockers are the beta adrenoceptor blocking drugs, blocking the effects of adrenergic stimulation mediated through these receptors. It is devoid of intrinsic sympathomimetic activity and it decreases heart rate and cardiac output. Further, Atenolol decreases plasma renin activity.

*ព័ត៌មានឱសថត្រូវបានរៀបរៀងដោយ អ៊ីម៉ាតុគឹ មេឌីក (ខេមបូឌា) ដោយផ្អែកលើប្រភពព័ត៌មានខាងក្រោម។ សម្រាប់ព័ត៌មានលម្អិត សូមស្វែងរកនៅក្នុងក្រដាសព័ត៌មាននៃឱសថនីមួយៗ ឬ សាកសួរទៅកាន់ក្រុមហ៊ុនឱសថឬតំណាងចែកចាយនៃឱសថនីមួយៗ។

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