AZIFAM Tablet

For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.

Indicated in the treatment of:

- Upper respiratory tract infections (including ear, nose and throat infections): Tonsillitis, sinusitis, otitis media and pharyngitis.

- Lower respiratory tract infections: community acquired pneumonias, acute bacterial exacerbations of chronic bronchitis, chronic obstructive pulmonary disease, bronchitis due to Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.

- Genitourinary tract infections (including sexually transmitted diseases): Urethritis, prostatitis, cervicitis, cervico-vaginitis and salpingitis due to N.gonorrhoae and C.trachomatis. Genital ulcer disease (chanchroid) in men due to Haemophilus ducreyi.

- Skin and skin structure infections: Folliculitis, furuncles, carbuncles, impetigo, pyoderma, infected ulcer, infected dermatitis, cellulitis and erysipelas due to S.aureus, S.pyogenes or S.agalactiae.

Dosage and Administration

Azithromycin should be administered as a single daily dose or as directed by the physician.

It can be taken with or without food.

For treatment of infections:

- Adults: 500-2000mg once a daily, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250-500mg once a daily for several days.

- Children and infants 6 months of age and older: Dose is based on body weight and must be determined by your doctor. The dose is usually 10-30mg/kg once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 5-10mg/kg once a day for several days.

- Infants younger than 6 months of age: Use and dose must be determined by your doctor.

For treatment of pharyngitis or tonsillitis:

- Adults: 500mg on day1, taken as a single dose. Then, 250mg on day2 through day5.

- Children 2 years of age and older: Dose is based on body weight and must be determined by your doctor. The dose is usually 12mg/kg once a day for 5 days.

- Children younger than 2 years of age: Use and dose must be determined by your doctor.

In patients with a known hypersensitivity to Azithromycin, erythromycin or any of the macrolide antibiotics.

The most common side effects are related to the gastrointestinal tract, e.g. nausea, flatulence, vomiting, diarrhea, or abdominal pain. Rare side effects include abnormal liver tests, allergic reactions, and nervousness.

Azithromycin should not be taken at the same time as aluminum or magnesium based antacids, because antacids will bind the azithromycin and prevent it from being absorbed from the intestine.

If you have severe kidney or liver disease, your physician may choose to lower the dose of azithromycin normally given or opt not to prescribe this medication at all.

Azithromycin is principally eliminated via the liver, caution should be exercised when azithromycin is administered to patients with impaired hepatic function. Before taking azithromycin, tell your doctor if you are allergic to it; or to other antibiotics (such as erythromycin, clarithromycin, telithromycin); or if you have any other allergies.