ALMETAMIN Tablet

For the treatment of acute urticaria, hay fever, chronic bronchial asthma, allergic rhinitis, drug eruption, atopic dermatitis, eczema, contact dermatitis and allergic conjunctivitis.

Dosage & Administration

 Adults and children over 12 years: Initial dosage is 1-2 tablets 1-4 times daily.

 Children 6-12 years: Initial dosage is 1/2-1 tablet 2-3 times daily.

 Infants 3-6 years: Initial dosage is 1/4-1/2 tablet 2-3 times daily.

If symptoms are improved, reduce dosage gradually to the minimal maintenance dose and the discontinue the administration. Do not use this tablet for a long time.

1. Patients with history of hypersensitivity to this medicine

2. Patients with glaucoma or patients who are in danger of glaucoma because of optical occlusion

3. Patients with lower tract obstructive disease (e.g. prostatomegaly etc.)

4. Neonate and premature infant

5. Patients with virus (especially hepatitis, herpes, varicella) infections. Patients with infection without effective antibacterial agent or systemic mycosis

6. Patients receiving live vaccine therapy.

1. Hypersensitivity reaction: rash

2. Psychiatric: mental disorder, nervousness, agitation, double vision, headache, insomnia, drowsiness and oppressive feeling.

3. Gastrointestinal: gastric ulcer, hydro dipsomania, heart burn, stomachache, nausea, vomiting, increase of appetite and diarrhea.

4. Urinary system: polyuria, dysuria.

5. Cardiovascular: hypertension.

6. Blood: leukocytosis, thrombosis.

7. Dermatological: edema, acne, pigmentation, subcutaneous bleeding, purpura, streak, hypertrichosis, alopecia, itching and dyshydrosis.

8. Endocrine: menstrual irregularly, diabetes, acute adrenocortical insufficiency and suppression of growth in infant.

9. Musculoskeletal: osteoporosis, steroid myopathy, myalgia and arthralgia.

10. Ophthalmic: subcapsular cataract and glaucoma.

11. Others: infections, malaise, moon shaped face, fever and weight gain.

In case of administering this drug with following drugs, it may potentiate actions of both drugs:

Central nervous system depressant, MAO inhibitor and alcoholic beverages.

Pregnancy

Teratogenic effects have been reported with the use of this tablet in animals.

In case of neonate born of mother who was taking adrenocortical hormones during the period of pregnancy, adrenal insufficiency can occur.

Safety in pregnancy has not been established, this tablet should not be used in pregnant women prior to or during labour unless the potential benefits outweigh the risks.

1. Since dizziness and drowsiness may occur, patients should be cautioned about the hazards of operating machinery or automobiles or engaging in other potentially dangerous tasks.

2. Slowly decrease dosage because symptoms such as fever, headache, anorexia, asthenia, myalgesia, arthralgia and shock syndrome may occur if patients suddenly discontinue administration after this tablet use continuously.

Warnings

Carefully administer to these patients:

Patients with tuberculous diseases, peptic ulcer, psychosis, herpes simplex keratitis, hypertension, thrombosis, subcapsular cataract, diabetes, osteoporosis and contagious disease.