PEPFIZ Effervescent tablets

The enzymes (papain and fungal diastase) present in PEPFIZ TABLETS act as digestive aid and simethicone helps in the symptomatic relief of flatulence, wind pains, bloating, abdominal distension and other symptoms associated with gastrointestinal gas.

1 tablet as and when required upto a maximum of 3 times a day.

These tablets are to be taken before meals.

Administration

Drop 1 tablet in half a glass of water (approx. 130mL) and drink as soon as the tablet dissolves.

Patients hypersensitive to papain,diastase, simethicone or any of the ingredient of this product.

Papain

Allergic sensitivity may cause symptoms ranging from an itchy palate to sneezing, rhinorrhea, watering itchy eyes, abdominal cramp, diarrhea, and diaphoresis. Other adverse effects may include gastric ulcer,esophageal perforation and hypernatremia.

Fungal Diastase

Hypersensitivity reactions have been reported.

Simethicone

Minor adverse effects: nausea and constipation. Rarely hypersensitivity reactions such as rash, pruritis, facial oedema, tongue oedema and respiratory difficulty have been reported.

PEPFIZ TABLETS may decrease the efficacy of alpha-glucosidase inhibition (acarbose and miglitol) class of anti-diabetic drugs.

The concomitant use simethicone and mineral oil (paraffin) based laxatives is not recommended since mixing of these two may diminish the efficacy.

The safety of PEPFIZ TABLETS has not been established in pregnant and lactating women.

It should be avoided unless prescribed by their phsicians.

This medicine should be used with caution in patients being treated for prostatitis as papain may reduce prostatitis symptoms.

This medicine should be avoided in patients with gastro-esophageal reflux disorder as papain may cause gastric ulcer and esophageal perforation.

This medicine should be avoided in patients using immunosuppressive therapy as papain may have immunostimulatory activity.

This medicine contain sodium and sunset yellow supra:

- Each tablet contains 419mg sodium. To be taken into consideration by patients on a controlled sodium diet.

- May cause allergic reactions.

Papain is a purified proteolytic substance derived from Carica Papaya (Caricaceae). This enzyme is a member of the papain family of cysteine proteinases that includes chymopapain, bromelain, actinidin, ficin, and aleurain, and the lysosomal cathepsins B,H,L,S,C and K.

Digestive Enzymes (amylase); Amylase (Diastase); Aspergillus oryzae; fungal enzyme are the related names/sources for diastase, which is a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans.

Simethicone is an anti-flatulent.