ORMED Tablet

ORMED may be used in the treatment of hepatic and intestinal amoebiasis, giardiasis, trichomoniasis of urogenital tract and bacterial vaginosis. Also used in the treatment and prophylaxis of susceptible anaerobic infections in dental and gastrointestinal surgery & in other mixed aerobic anaerobic infections. ORMED is also advocated in the management of H.pylori duodenal ulcer in combination with other drugs.

Dosage and Administration:

Amoebiasis

Adults: 500mg twice daily for 5-7 days

Children: 25mg/kg once daily for 5-10 days

Amoebic dysentery

Adults: 1.5g once daily for 3 days

Children: 40mg/kg once daily for 3 days

Giardiasis:

Adults: 1.5g once daily for 1-2 days

Children: 40mg/kg for 2 days

Trichomoniasis

Adults: 1.5g once or 500mg once daily for 5-7 days

Anaerobic bacterial infections

Initiate oral therapy as soon as possible after I.V. infusion.

Adults: 500mg twice daily for 5-10 days

Children: 10mg/kg twice daily

In patients hypersensitive to ornidazole and other imidazoles. There is no evidence of accumulation when used in pregnant women. Therefore dosage regimen requires no adjustment during pregnancy.

The most frequently encountered side effect is dizziness, alone or in combination with other adverse reactions. The other side effects occurring to a lesser extent are nausea, pyrosis, intestinal spasms and metallic taste. Vertigo, fatigue and other discomforts such as loose stools, insomnia, skin rash and headache have also been reported.

See "Contraindication".

The antimicrobial activity of ORMED is due to the reduction of the nitro group to a more reactive amine that attacks microbial DNA, brings about loss of helical structure of DNA and subsequent DNA breakage thus inhibiting further synthesis and causing degradation of existing DNA.