MIFESTAD Tablet

Emergency contraception within 120 hours after unprotected sexual intercourse.

1 tablet of Mifestad 10 can be used up to 120 hours after intercourse.

Known hypersensitive to mifepristone or any compound of the drug.

- Pregnancy

- Chronic adrenal failure

- Severe uncontrolled asthma

- Renal or hepatic impairment.

- Inherited porphyrias.

- Breast-feeding

bleeding, nausea, vomiting, diarrhea, lower abdominal pain, fatigue, headache, dizziness, breast tenderness.

- Should be used with care in patients with less severe asthma or with chronic obstructive airways diseases, haemorrhagic or cardiovascular disease or associated risk factors, or anaemia.

- Should be used with care in patients receiving long-term corticosteroid treatment, a corticosteroid may need to be given if accute adrenal suppression is suspected.

- Care is also required in patients receiving anticoagulants because of the increased risk of severe bleeding

Aspirin and NSAIDs should be avoided to use concomitantly with mifepristone because of a theoretical risk that prostaglandin synthetase inhibitors may alter the efficacy of mifepristone.

　- Emergency contraception is a palliative, use only in case of emergency and it could not be replaced regular contraception. Women who present for repeated courses of emergency contraception should be advised to consider a long-term method of contraception.

- Emergency contraception could not have the desired effect in all cases. If the unprotected sexual intercourse time was not determined or the women has had an unprotected sexual intercourse over 120 hours in one period, pregnancy may occur. So, treatment with mifepristone 10mg after the second sexual intercourse may be ineffective. If the period is later than 5 days, unusual haemorrhagic on the day of the period is expected, or pregnancy is suspected due to any other cause, patients have to determine that pregnancy does not occur.

- Unprotected intercourse after treatment can increased the risk of an unwanted pregnancy.

- Should not repeat treatmet in one period because of the risk of menstruation disorder.

- Should be used with care in patients with less severe asthma or with chronic obstructive airways diseases, haemorrhagic or cardiovascuar disease or associated risk factors, or anaemia.

- Should be use with care in patients receiving long-term corticosteroid treatment, a corticosteroid may need to be given if accute adrenal supression is suspected.

- Care is also required in patients receiving anticoagulatns because of the increaesd risk of severe bleeding.

Mifepristone is a synthetic steroid with anti-progesterone function, which will competitively occupy the progesterone receptor. This effect will result in terminating pregnancy.