METHACIN Capsule
ក្រុមហ៊ុនផលិតឱសថ:
HOVID Bhd., Malaysia
- សារធាតុសកម្ម
- ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់
- ហាមប្រើ
- ផលរំខាន
- អន្តរប្រតិកម្ម
- ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន
- ការប្រុងប្រយ័ត្នជាពិសេស
- សកម្មភាពឱសថ បរិយាយប័ណ្ណឱសថ
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សារធាតុសកម្ម
Indomethacin 25mg
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ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់
For treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, other rheumatic disorders and acute gout.
Dosage and Administration
Adults: Oral, 25mg 2-4 times daily, the dosage may be increased to 150-200mg daily, if necessary, as tolerated.
Note: Some types of arthritis may require up to 2 weeks therapy for noticeable improvement and up to 1 month for maximum effectiveness.
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ហាមប្រើ
In patients with peptic ulcer or a history of gastrointestinal lesions, or to those who are sensitive to aspirin.
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ផលរំខាន
Headache, dizziness or lightheadedness, gastrointestinal disturbances, depression, tinnitus and blurred vision with prolonged therapy, gastrointestinal ulceration and bleeding, oedema, weight gain and skin rashes.
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អន្តរប្រតិកម្ម
- Co-administration of alcohol or other anti-inflammatory medications may enhance the risk of ulcerogenic effects.
- Concurrent use with aspirin or other salicylates may increase of gastrointestinal side effects without providing additional symptomatic relief.
- Caution in patients receiving the following drug therapy Frusemide, anticoagulants, lithium, probenecid.
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ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន
Safety for use has not been established in children under 14 years of age, and in pregnancy and lactation.
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ការប្រុងប្រយ័ត្នជាពិសេស
RISK OF GI ULCERATION, BLEEDING AND PERFORATION WITH NSAID
Serious GI toxicity such as bleeding, ulceration and perforation can occur at any time, with or without warning symptoms, in patients treated with NSAID therapy. Although minor upper GI problems (e.g. dyspepsia) are common, usually developing early in therapy, prescribers should remain alert for ulceration and bleeding in patients treated with NSAIDs even in the absence of previous GI tract symptoms.
Studies to date have not identified any subset of patients not at risk of developing peptic ulceration and bleeding. Patients with prior history of serious adverse events and other risk factors associated with peptic ulcer disease (e.g. alcoholism, smoking, corticosteroid therapy) are at increased risk. Elderly or debilitated patients seem to tolerate ulceration or bleeding less than other individuals and account for most spontaneous reports for fatal GI events.
- Caution in patients with impaired renal or hepatic function, and to those with bleeding disorders; epilepsy, parkinsonism, psychiatric disorders; or conditions predisposing to fluid retention such as compromised cardiac failure.
- This drug is preferably administered after meals or with food to reduce gastrointestinal irritation.
- This medication may cause drowsiness in some patients. Caution when driving or operating machinery. Avoid alcoholic beverages.
- Elderly patients may be more susceptible to the toxic effects of indomethacin.
- Indomethacin may mask the signs of infections, the drug should be used with extra care in the presence of existing controlled infection.
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សកម្មភាពឱសថ
Indomethacin has analgesic, anti-inflammatory and antipyretic actions. Its mode of action may involve inhibition of prostaglandin synthesis.
Oral absorption is rapid but is delayed by antacids. Plasma protein binding is extensive; it undergoes hepatic metabolism and both renal and faecal excretions.
*ព័ត៌មានឱសថត្រូវបានរៀបរៀងដោយ អ៊ីម៉ាតុគឹ មេឌីក (ខេមបូឌា) ដោយផ្អែកលើប្រភពព័ត៌មានខាងក្រោម។ សម្រាប់ព័ត៌មានលម្អិត សូមស្វែងរកនៅក្នុងក្រដាសព័ត៌មាននៃឱសថនីមួយៗ ឬ សាកសួរទៅកាន់ក្រុមហ៊ុនឱសថឬតំណាងចែកចាយនៃឱសថនីមួយៗ។
ប្រភពព័ត៌មាន៖
- ក្រដាសព័ត៌មាននៃឱសថសម្រាប់អ្នកជំនាញវេជ្ជសាស្ត្រដែលប្រើប្រាស់នៅប្រទេសជប៉ុន (Pharmaceutical and Medical Devices Agency, Pmda): https://www.pmda.go.jp
- ព័ត៌មានសង្ខេបនៃឱសថសម្រាប់អ្នកជំងឺដែលប្រើប្រាស់នៅប្រទេសជប៉ុន: http://www.rad-ar.or.jp