MEDIXON Tablet

- Systemic fungal infection.

- Recent immunization and known hypersensitivity to the components.

- Long treatment of this drug is contraindicated to duodenal and peptic ulcer, osteoporosis, patients with a history of psychosis, herpes.

Adverse reactions occur in a prolonged usedor in a large dose e.g.: Fluid and electrolyte disturbances, muscle weakness, impaired wound healing, increased blood pressure, posterior subcapsular cataracts, suppression of growth in childrem, adrenal insufficiency, Cushing's syndrome, osteoporosis, and peptic ulcer.

- It is recommended to administer concomitantly with food to minimize the gastrointestinal infection.

- Administered concomitantly with other nonsteroid antiinflammation or antirrheumatic drugs may cause gastrointestinal hemorrhage.

- If this drug administered concomitantly with antidiabetic drugs, the recommended dosage should be reduced.

- Patients who received smallpox vaccination or other immune especially in large doses.

Not recommended in pregnant women and nursing mother, except if clearly needed. Infants born of mothers who have received substantial doses of corticosteroid during pregnancy should be carefully observed and evaluated for signs of adrenal insufficiency.

- not recommended in pregnant women and nursing mother, except if clearly needed. Infants born of mothers who have received substantial doses of corticosteroid during pregnancy should be carefully observed and evaluated for signs of adrenal insufficiency.

- While on corticosteroids therapy patients should not be vaccinated against smallpox or other immune especially on high dose, because of possible hazards or neurological complications.

- if corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur.

- corticosteroid effects may increase in patients with hypothyroidism or cirrhosis.

- not recommended to patients with ocular herpes simplex because it may cause corneal perforation.

- Administration of this drug may mask some signs of infection U231:V231and new infections may appear during their use.

- Concomitant Administration of prednisolone and cyclosporine may result in decreased plasma clearance of prednisolone, and plasma concentrations of cyclosporine may be increased during Concomitant therapy with methylprednisolone.

- Seizures reportedly have occurred in adult and pediatric patients receiving high-dose corticosteroid therapy concurrently with cyclosporine.P231

Methylprednisolone is a moderately potent glucoocrticoid which has only slight mineralocorticoid ctivity. It has greater antiinflammatory potency than prednisolone, even less tendency than prednisolone to induce sodium and water retention.

Unbound blucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic reeptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and supress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis or potent mediators of inflammation such as prostaglandins and leukotrienes.