MEDIXON Tablet

ក្រុមហ៊ុនផលិតឱសថ:

 

SANOFI-AVENTIS, Vietnam

ក្រុមហ៊ុនចែកចាយឱសថនៅប្រទេសកម្ពុជា:

 

Dynamic Pharma

  • សារធាតុសកម្ម
  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់
  • ហាមប្រើ
  • ផលរំខាន
  • អន្តរប្រតិកម្ម
  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន
  • ការប្រុងប្រយ័ត្នជាពិសេស
  • សកម្មភាពឱសថ
  • បរិយាយប័ណ្ណឱសថ 
  • សារធាតុសកម្ម

    1. MEDIXON 4:

    Methylprednisolone 4mg

    2. MEDIXON 16:

    Methylprednisolone 16mg

  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់

  • ហាមប្រើ

    - Systemic fungal infection.

    - Recent immunization and known hypersensitivity to the components.

    - Long treatment of this drug is contraindicated to duodenal and peptic ulcer, osteoporosis, patients with a history of psychosis, herpes.

  • ផលរំខាន

    Adverse reactions occur in a prolonged usedor in a large dose e.g.: Fluid and electrolyte disturbances, muscle weakness, impaired wound healing, increased blood pressure, posterior subcapsular cataracts, suppression of growth in childrem, adrenal insufficiency, Cushing's syndrome, osteoporosis, and peptic ulcer.

  • អន្តរប្រតិកម្ម

    - It is recommended to administer concomitantly with food to minimize the gastrointestinal infection.

    - Administered concomitantly with other nonsteroid antiinflammation or antirrheumatic drugs may cause gastrointestinal hemorrhage.

    - If this drug administered concomitantly with antidiabetic drugs, the recommended dosage should be reduced.

    - Patients who received smallpox vaccination or other immune especially in large doses.

  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន

    Not recommended in pregnant women and nursing mother, except if clearly needed. Infants born of mothers who have received substantial doses of corticosteroid during pregnancy should be carefully observed and evaluated for signs of adrenal insufficiency.

  • ការប្រុងប្រយ័ត្នជាពិសេស

    - not recommended in pregnant women and nursing mother, except if clearly needed. Infants born of mothers who have received substantial doses of corticosteroid during pregnancy should be carefully observed and evaluated for signs of adrenal insufficiency.

    - While on corticosteroids therapy patients should not be vaccinated against smallpox or other immune especially on high dose, because of possible hazards or neurological complications.

    - if corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur.

    - corticosteroid effects may increase in patients with hypothyroidism or cirrhosis.

    - not recommended to patients with ocular herpes simplex because it may cause corneal perforation.

    - Administration of this drug may mask some signs of infection U231:V231and new infections may appear during their use.

    - Concomitant Administration of prednisolone and cyclosporine may result in decreased plasma clearance of prednisolone, and plasma concentrations of cyclosporine may be increased during Concomitant therapy with methylprednisolone.

    - Seizures reportedly have occurred in adult and pediatric patients receiving high-dose corticosteroid therapy concurrently with cyclosporine.P231

  • សកម្មភាពឱសថ

    Methylprednisolone is a moderately potent glucoocrticoid which has only slight mineralocorticoid ctivity. It has greater antiinflammatory potency than prednisolone, even less tendency than prednisolone to induce sodium and water retention.

    Unbound blucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic reeptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and supress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis or potent mediators of inflammation such as prostaglandins and leukotrienes.

*ព័ត៌មានឱសថត្រូវបានរៀបរៀងដោយ អ៊ីម៉ាតុគឹ មេឌីក (ខេមបូឌា) ដោយផ្អែកលើប្រភពព័ត៌មានខាងក្រោម។ សម្រាប់ព័ត៌មានលម្អិត សូមស្វែងរកនៅក្នុងក្រដាសព័ត៌មាននៃឱសថនីមួយៗ ឬ សាកសួរទៅកាន់ក្រុមហ៊ុនឱសថឬតំណាងចែកចាយនៃឱសថនីមួយៗ។

ប្រភពព័ត៌មាន៖

- ក្រដាសព័ត៌មាននៃឱសថសម្រាប់អ្នកជំនាញវេជ្ជសាស្ត្រដែលប្រើប្រាស់នៅប្រទេសជប៉ុន (Pharmaceutical and Medical Devices Agency, Pmda): https://www.pmda.go.jp

- ព័ត៌មានសង្ខេបនៃឱសថសម្រាប់អ្នកជំងឺដែលប្រើប្រាស់នៅប្រទេសជប៉ុន: http://www.rad-ar.or.jp