MEBAAL Tablet

Peripheral neuropathies like diabetic neuropathy, alcoholic neuropathy, drug induced neuropathy, trigeminal & occupational neuralgia, bells palsy and Megaloblastic anemia.

Dose

Usually for adults, orally administer 1 tab 3 times daily or 1 tab OD.

The dosage should be adjusted according to age of patient and severity of symptoms.

Hypersensitivity to Methylcobalamin.

Anaphylactic reaction: anaphylactic reaction such as decrease in blood pressure or dyspnea may occur. Patient should be monitored after administration of dose.

See the package insert about the details below:

- Antibiotics

- Cholestyramine

- Colchicine

- Colestipol

- H2 blockers (cimetidine, famotidine, nizatidine, ranitidine)

- Metformin

- Nitrous oxide

- Para-amino salicylic acid

- Potassium chloride

- PPI (lansoprazole, omeprazole, pantoprazole, rabeprazole)

The use of Methylcobalamin in deficiency states or to treat any medical condition requires medical supervision. A typical dose as nutritional supplements used by pregnant women and nursing mothers is 12 mcg daily. Pregnant women and nursing mothers should only use doses higher than this if recommended by their physicians. Administration of doses greater than 10mcg daily may produce a hematological response in those with anemia secondary to folate deficiency.

Methylcobalamin is one of the two active coenzyme forms of vitamin B-12. It is a co-factor to the enzyme methionine synthetase that function to transfer methyl groups for the regeneration of methionine from homocysteine. It is closely involved in folate metabolism, and is pivotal for the synthesis of purines and pyrimidines. It also acts as a methyl donor for the synthesis of lecithin, a major component of myelin sheath.

l Methylcobalamin pays an important role in transmethylation as a coenzyme of methionine synthetase in synthesis of methionine from homocysteine.

l Methylcobalamin is well transported to nerve cell organelles, and promotes nucleic acid and protein synthesis. It is better transported to nerve cell organelles than cyanocobalamin in animals.

l Methylcobalamin promotes axonal regeneration. It normalizes axonal skeletal protein transport in sciatic nerve cells from animal’s models with streptozotocin induced diabetes mellitus. It exhibits neuropathologically and electrophysiologically inhibitory effects on nerve degeneration in neuropathies induced by drugs, such as adriamycin, acrylamide, and vincristine models of axonal degeneration in mice and neuropathies in animals with spontaneous diabetes mellitus.

l Methylcobalamin promotes myelination (phospholipid synthesis). It promotes the synthesis of lecithin, the main constituent of medullary sheath lipid and increases myelination of neurons in animal tissue culture more than cobalamide does.

l Methylcobalamin restores delayed synaptic transmission and diminished neurotransmitters to normal. It restores and plate potential induction early by increasing nerve fiber excitability in crushed sciatic nerve. In addition, it also normalizes diminished brain tissue levels of acetylcholine in animals fed a choline-deficient diet.

l Methylcobalamin promotes the maturation and division of erythroblasts, thereby alleviating anemia. It also promotes nucleic acid synthesis in bone marrow and promotes the maturation and division of erythroblasts, thereby increasing erythrocyte production.

l Methylcobalamin brings about a rapid recovery of diminished red blood cell, hemoglobin, and hematocrit in vitamin B-12 deficient animals.