GLUMIN Tablet

Treatment for newly diagnosed maturity-onsel patients with or without overweight problem and failure of dietetic therapy.

-As a combination therapy for diabetics unresponsive to single therapy of sulfonylurea either primary or secondary.

-Adjuvant therapy to lower insulin dosage if required.

GLUMIN® should be taken in divided doses with meals or after meals.

Dosage :

Tablet 500mg: 500 mg tablet, 3 times daily

Tablet 850mg: initial dose 850mg tablets, 1 time daily (morning), Maintenance dose: 850mg tablets, twice daily (morning and night)

Patients with cardiac failure, renal dysfunction, impaired hepatic function, dehydration and alcoholism, diabetic coma, ketoacidosis, myocardial infarction, chronic or acute diseases states associated with tissue hypoxia, diseases states associated with lactic acidosis such as shock, pulmonary insufficiency, lactic acidosis history.

GLUMIN® causes reversible gastrointestinal tract side effects including anorexia, abdominal disturbances, nausea, vomiting, metalic taste and diarrhea.

Lactic acidosis can occur but death incidences 10-15 times less than phenformin and less than hypoglycemia case caused by glibenclamide/sulfonylurea.

Lactic acidosis can be treated with sodium bicarbonate.

Individual case with metformin are megaloblastic anemia, pneumonitas, vasculitis.

Acarbose a-glucosidase inhibitor decreases bioavailability and average maximum concentration plasma of metformin but the onset time is not changed.

-Guar gum can decrease absorption rate of metformin and decrease blood concentration of metformin.

-Cimetidine inhibits renal tubular secretion metformin competitively and increases area under plasma concentration of metformin vs time curve and decreases renal excretion of metformin.

- Oral anticoagulant phenprocoumon increases elimination of this drugs, increases hepatic blood flow and hepatic extraction as metformin effect at microsomal enzyme activity.

Although embryonic side effects do not occur on administration metformin in diabetic pregnant women, insulin better than oral anti hyperglycemia agent for hyperglycemia controlled in pregnancy.

-Not recommended for use in nursing mothers.

- Stimulating conditions of hypoxia and lactic accumulation may cause seriously lactic acidosis, GLUMIN should not be used in patients with cardiovascular diseases, renal dysfunction, impaired hepatic function, dehydration and alcoholism.

- Long-term therapy of GLUMIN, can causes failure absorption of vitamin B12 and folic acid in the gastrointestinal tract. Therefore, serum B12 levels should be checked every year.

- Although embryonic side effects do not occur on administration metformin in diabetic pregnant women, insulin better than oral anti hyperglycemia agent for hyperglycemia controlled in pregnancy.

- Not recommended for use in nursing mothers.

- The possibly of interactions between metformin with certain anticoagulants, dosage of anticoagulant may adjustment.

- In patient of elderly, serious infection and trauma conditions should be used with caution.