GLUCOPHAGE 850mg Tablet

គុណភាពព្យាបាល
សំរាប់ព្យាបាលជម្ងឺទឹកនោមផ្អែមប្រភេទ2 (Type 2) ក្នុងក្រុម Biguanide
- ចំពោះមនុស្សពេញវ័យ ត្រូវប្រើ Glucophage 850mg តែ1មុខ ឬប្រើជាមួយឱសថទឹកនោមផ្អែមផ្សេងទៀត ឬ Insulin
- ចំពោះក្មេងចាប់ពីអាយុ10ឆ្នាំ និង ក្មេងជំទង់ Glucophage 850mg តែ1មុខ ឬប្រើជាមួយឱសថ Insulin។
កំរិតនិងរបៀបប្រើ
- កំរិតប្រើ Glucophage 850mg ត្រូវកំណត់ប្រើដោយគ្រូពេទ្យ ក្រោយពីបានលទ្ធផលនៃការពិនិត្យជាតិស្ករក្នុងឈាម
- កំរិតប្រើដំបូងសំរាប់កុមារអាយុ10ឆ្នាំ និងក្មេងជំទង់ត្រូវប្រើ Glucophage 500mg ឬ 850mg លេបម្ដងក្នុង1ថ្ងៃ
- ចំពោះក្មេង កំរិតប្រើអតិបរមា 2ក្រាមក្នុង1ថ្ងៃ លេបពី 2 ទៅ 3ដងក្នុង1ថ្ងៃ
- ចំពោះមនុស្សពេញវ័យ កំរិតប្រើអតិបរមា 3ក្រាមក្នុង1ថ្ងៃ លេបពី 2 ទៅ 3ដងក្នុង1ថ្ងៃ
- ក្នុងករណីខ្សោយមុខងារតម្រងនោម កំរិតនាការប្រើប្រាស់ឱសថ ត្រូវប្រែប្រួលទៅតាមសភាពជម្ងឺ
- ត្រូវលេបក្នុងពេលកំពុងពិសាអាហារ ឬក្រោយពេលពិសាអាហារភ្លាមៗ។
- ត្រូវគោរពតាមវេជ្ជបញ្ជាយ៉ាងម៉ឺងម៉ាត់។

As an adjunct to adequate diet and exercise this medicine is an oral antidiabetic agent (biguanide) intended for the treatment of type 2 diabetes. In adults, this medicine may be given alone or with oral antidiabetic agents, or with insulin. In children from 10 years old and adolescents, this medicine may be given alone or with insulin.

A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet therapy.

Dosage

The dosage is determined by your doctor on an individual basis according to the results of laboratory blood glucose measurement.

The initial dosage: Children from 10 years old and adolescents: Glucophage 850mg once daily

Adults: Glucophage 850mg 2-3 times daily.

The maximum dose: 2g daily in children and 3g daily in adults (taken as 2-3 divided doses).

In case of decreased renal function, the dosage should be adjusted based on renal function.

Oral route. Swallow the tablets without chewing during or at the end of meals.

Duration of treatment: This drug must be taken daily without interruption. In case you stop the treatment, consult your doctor.

ហាមប្រើ
- អ្នកធ្លាប់ងាយមានប្រតិកម្មអាល្លែកហ្ស៊ីជាមួយ Metformin hydrochloride ឬសមាសធាតុផ្សំណាមួយនៃឱសថនេះ
- អ្នកជម្ងឺទឹកនោមផ្អែមធ្ងន់ធ្ងរ (Acidocetose)
- អ្នកមានជម្ងឺតម្រងនោមខ្សោយ
- អ្នកជម្ងឺខ្សោយបេះដូង ផ្លូវដង្ហើមខ្សោយ និងគាំងបេះដូង បណ្ដាលមកពីការផ្ដល់អុកស៊ីសែនមិនគ្រប់គ្រាន់
- អ្នកជម្ងឺខូចមុខងារថ្លើម
- អ្នកជម្ងឺរាកធ្ងន់ធ្ងរ ឬក្អួត
- អ្នកជម្ងឺផឹកស្រាច្រើន
- ក្នុងអំឡុងពេលបំបៅដោះកូន
- អ្នកជម្ងឺឆ្លងដោយមេរោគ
- ផ្អាក2ថ្ងៃក្រោយពីការថតឆ្លុះដោយផលិតផល Iode។

- known hypersensitivity to metformin hydrochloride or any of the product ingredients,

- severe destabilisation of diabetes (ketoacidosis or pre-coma),

- renal insufficiency, even if moderate (impairment kidney function with increased blood creatinine levels or decreased creatinine clearance <60ml/min),

- infectious diseases (e.g. respiratory tract infection, urinary tract infection),

- following an X-ray examination involving the use of iodinated contrast media (e.g. intravenous urography, angiography),

- disease which may cause tissue hypoxia (heart failure, recent myocardial infarction, respiratory insufficiency, shock),

- hepatic insufficiency (impaired liver function),

- persistent or severe diarrhoea, recurrent vomiting,

- excessive consumption of alcoholic beverages,

- during breast-feeding.

Very common: Gastrointestinal discomfort such as nausea, vomiting, diarrhoea, abdominal pain and loss or appetite may occur especially at the beginning of treatment. These symptoms are generally transient and can be reduced by taking the tablets with meals. Should symptoms persist, stop taking the treatment and consult your doctor.

Common: taste disturbance.

Very rare:

-Lactic acidosis is a very serious complication, which results in vomiting, abdominal pain with muscle cramps and/or a general feeling of malaise with severe fatigue and which requires specific treatment. If this occurs you should stop taking this drug immediately and consult your doctor promptly. Lactic acidosis is a medical emergency and must be treated in a hospital.

- Skin reactions such as erythema (red skin), itching or urticaria (eruption with itching).

- Decreased vitaminB12 levels (to take into consideration by your doctor if you are suffering from megaloblastic anaemia).

Isolated cases: liver function tests abnormalities or hepatitis resolving upon this drug discontinuation.

Inform your doctor or your pharmacist if you are taking or have recently taken another drug, e.g. corticosteroids, NSAIDs, antihypertensive agents of the angiotensin-converting enzyme inhibitors class, diuretics, beta2 agonists (e.g. salbutamol, terbutaline), iodinated contrast media or medications containing alcohol).

ចំពោះស្ត្រីមានផ្ទៃពោះ មិនត្រូវប្រើ Glucophage ត្រូវប្រើ Insulin ជំនួសវិញ។ ត្រូវពិគ្រោះជាមួយគ្រូពេទ្យ ប្រសិនបើអ្នកមានផ្ទៃពោះ និងបំបៅកូន។

- During pregnancy, treatment of diabetes is based on insulin therapy. If you discover that you are pregnant while taking this medicine, your treatment will be replaced by insulin. Inform your doctor so that she/he may make the necessary changes to your treatment. Inform your doctor if you wish to become pregnant.

- This drug is contra-indicated during breast-feeding.

- As a general rule, if you are pregnant or breast-feeding you should always ask your doctor for advice before taking a medication.

ការប្រុងប្រយ័ត្ន
- មុន និងពេលកំពុងប្រើ ត្រូវពិនិត្យមើលមុខងារតម្រងនោម ព្រោះMetformin ជាសារជាតិសកម្មដែលមាននៅក្នុង Glucophage ភាគច្រើនបញ្ចេញចោលតាមតម្រងនោម។
- ឱសថមួយចំនួនដូចជា Corticoides, Diruetiques, Les Beta 2-agonistes, Les inhibiteurs de I’enzyme de conversion de I’angiotensine និងជម្ងឺមួយចំនួនទៀតដូចជា ផ្ដាសាយ ជម្ងឺផ្លូវដង្ហើម ឬជម្ងឺផ្លូវទឹកនោមអាចបណ្ដាលអោយជម្ងឺមានសភាពប្រែប្រួល។
- ចំពោះស្ត្រីមានផ្ទៃពោះ មិនត្រូវប្រើ Glucophage ត្រូវប្រើ Insulin ជំនួសវិញ។
- ត្រូវពិគ្រោះជាមួយគ្រូពេទ្យ ប្រសិនបើអ្នកមានផ្ទៃពោះ និងបំបៅកូន។

Vomiting, abdominal pain with muscle cramps and/or a general feeling of malaise with severe fatigue occurring during therapy may be signs of serious destabilisation of your diabetes (diabetic ketoacidosis or lactic acidosis) requiring specific treatment.

- Your doctor will prescribe periodic laboratory tests to determine your blood glucose and will check your kidney function (creatinine levels or creatinine clearance) before treatment initiation and regularly thereafter since metformin is excreted mainly by the kidneys. Special caution should be exercised in situations where kidney function may become impaired, e.g. in the elderly or when initiating antihypertensive treatment of diuretic treatment and when starting treatment with a NSAIDs.

- Certain illnesses or medications such as corticosteroids, diuretics, beta2 agonists and angiotensin-converting enzyme inhibitors may cause more or less severe destabilisation of diabetes. You should inform your doctor of any other treatment you are receiving and of any infectious illness such as influenza, respiratory tract infection or urinary tract infection.

- If you are scheduled to undergo X-ray examinations involving the use of iodinated contrast media, such as intravenous urography or angiography, your doctor will ask you to discontinue treatment with this medicine prior to or at the time of the test and will not resume treatment until 48 hours after the test, after ensuring that your kidneys are functioning normally. If you are hospitalized for tests, a surgical procedure, or for any other reason, advise your doctor that you are taking this medicine. Avoid consumption of alcoholic beverages.

- In children, a follow-up of the metformin effect on growth and puberty especially in pre-pubescent children is recommended.