CIPRALEX 10mg Tablet

Cipro-Denk 500 is an antibiotic belonging to the fluoroquinolone group. The active substance is ciprofloxacin. Ciprofloxacin works by killing bacteria that cause infections. It only works in certain strains of bacteria.

As a fluoroquinolone antibiotic, ciprofloxacin has a bactericidal effect based on inhibition of topoisomeraseⅡ(DNA gyrase) and topoisomeraseⅣ. Both enzymes are needed for bacterial DNA replication, transcription, recombination and repair.

Antibacterial spectrum of efficacy

The prevalence of acquired resistances can vary for certain species with regard to geographical and temporal aspects. Knowledge of the local resistance patterns is therefore of importance, particularly in the treatment of severe infections.

If, due to the local resistance status, the use of ciprofloxacin seems questionable for at least some forms of infection, expert advice should be sought.

Commonly susceptible species are:

- Aerobic Gram-positive microorganisms like Bacillus anthracis and Staphylococcus saprophyticus,

- Aerobic Gram-negative microorganisms like Enterobacter aerogenes, Enterobacter cloaceae, Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitidis, Proteus vulgaris, Salmonella enterica (including S.typhi/parathyphi), Serratia marcescens and Shigella ssp.

- Other microorganism like Chlamydia trachomatis, Chlamydophila pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae.

Species in which acquired resistance may pose a problem during use:

Enterococcus faecalis, some subspecies of Staphylococcus aureus, and some aerobic Gram-negative microorganisms.

Inherently resistant species are:

Enterococcus faecium, Stenotrophomas maltophilia, Bacteriodes ssp., Clostridium difficile, Treponema pallidum and Ureaplasma urealyticum.