CEFIGET Capsule

ក្រុមហ៊ុនផលិតឱសថ:

 

Opal Laboratiores Ltd, Pakistan

ក្រុមហ៊ុនចែកចាយឱសថនៅប្រទេសកម្ពុជា:

 

ALLIANCE PHARMA CAMBODGE

  • សារធាតុសកម្ម
  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់
  • ហាមប្រើ
  • ផលរំខាន
  • អន្តរប្រតិកម្ម
  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន
  • ការប្រុងប្រយ័ត្នជាពិសេស
  • សកម្មភាពឱសថ
  • បរិយាយប័ណ្ណឱសថ 
  • សារធាតុសកម្ម

    Cefixime 400mg

  • ប្រសិទ្ធិភាពព្យាបាល និង កម្រិតប្រើប្រាស់

    Indications

    - uncomplicated urinary tract infections

    - otitis media

    - pharyngitis, tonsillitis

    - acute bronchitis, acute exacerbations of chronic bronchitis

    - uncomplicated gonorrhea (cervical/urethral)

    Dosage

    Adults and children over 10 years: 200-400mg daily according to the severity of infection, given 1-2 time(s) daily.

    Children: 8mg/kg/day, 1-2 time(s) daily. 4mg/kg every 12 hours except for urinary tract infection where once daily dosing must be used.

    6 months -1 year:3.75mL

    1-4 years: 5mL daily

    5-10 years: 10mL daily

    Children weighing more than 50k or older than 10 years should be treated with the recommended adult dose.

    Otitis Media: should be treated with the suspension.

    Duration of Therapy

    The usual course of treatment is 7 days. This may be continued for up to14 days if required.

    In the treatment of infections due to S.pyogenes, a therapeutic dosage should be administered for at least 10 days.

    Special Populations

    Renal Insufficiency

    This medicine may be administered in the presence of impaired renal function. Normal dose and schedule may be given in patients with creatinine clearances of 20mL/min or greater. In patients who se creatinine clearance is less than 20mL/min, it is recommended that a dose of 200mg once daily should not be exceeded. The dose and regimen for patients who are maintained on chronic ambulatory peritoneal dialysis of hemodialysis should follow the same recommendation as that for patients with creatinine clearances of less than 20mL/min.

    Directions for Preparing Oral Suspension

    Fill previously boiled and cooled water up to the line mark on the bottle and shake vigorously.

    The reconstituted suspension can be used for up to 7 days, when stored at room temperature and up to 14 days when refrigerated without significant loss of potency. Keep tightly closed. Shake well before using.

    Discard unused portion after 14 days.

  • ហាមប្រើ

    Patients with hypersensitivity to any coponent of this medicine, patients with known allergy to cephalosporins group, and children less than six months.

  • ផលរំខាន

    Gastrointestinal disturbance: Diarrhea (if severe diarrhea occurs, cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence, Pseudomembranous colitis.

    Central nervous system disturbance: Headache, dizziness, seizures.

    Hepatic Disorders: Transient rises in liver transaminases, alkaline phosphatase, jaundice.

    Others: Hypersensitivity reactions which usually subside upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase. Increase in prothrombin time. Genital pruritis, vaginitis.

  • អន្តរប្រតិកម្ម

    Anticoagulants: Care should be exercised in patients receiving anticoagulants and cefixime concomitantly due to the possibility that cefixime may increase prothrombin time.

    Carbamazepine: Elevated carbamazepine levels have been reported, when cefixime is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

    Laboratory Interactions

    - A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide.

    - A false-positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solutions or with copper sulphate test tablets, but not with tests based on enzymatic glucose oxidase reactions.

    - A false-positive direct Coombs test has been reported during treatment with cephalosporin antibiotics, therefore it should be recognized that a positive Coombs test may be due to the drug.

  • ស្ត្រីមានផ្ទៃពោះ និង ស្ត្រីបំបៅដោះកូន

    Pregnancy

    There are no adequate and well-controlled studies in pregnant women. Cefixime should not be used in pregnancy unless considered essential by the physician.

    Nursing mothers

    It is not known whether cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug.

  • ការប្រុងប្រយ័ត្នជាពិសេស

    - Cephalosporins should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and cephalosporins.

    - Cefixime should be administered with caution in patients with markedly impaired renal function.

    - Treatment with broad spectrum antibiotics alters the normal flora of the colon and may permit overgrowth of clostridia. Pseudomembranous colitis is associated with the use of broad-spectrum antibiotics (including macrolides, semi-synthetic penicillins, lincosamides and cephalosporins); it is therefore important to consider its diagnosis in patients who develop diarrhea in association with the use of antibiotics. Symptoms of pseudomembranous colitis may occur during or after antibiotic treatment.

    - Broad-spectrum antibiotics such as cefixime should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

    - Do not use cefixime to treat S.aureus as this strain of staphylococci is resistant to cefixime.

  • សកម្មភាពឱសថ

    It has bactericidal activity of gram poditive and gram negative . like other cepholosporins, cefixime exhibits its bactericidal action by binding to specific penicillin-binding proteins located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacteria cell wall autolytic enzyme such as autolysins. The antibacterial effect results from inhibition of mucopeptide synthesis in the bacterial cell wall.

*ព័ត៌មានឱសថត្រូវបានរៀបរៀងដោយ អ៊ីម៉ាតុគឹ មេឌីក (ខេមបូឌា) ដោយផ្អែកលើប្រភពព័ត៌មានខាងក្រោម។ សម្រាប់ព័ត៌មានលម្អិត សូមស្វែងរកនៅក្នុងក្រដាសព័ត៌មាននៃឱសថនីមួយៗ ឬ សាកសួរទៅកាន់ក្រុមហ៊ុនឱសថឬតំណាងចែកចាយនៃឱសថនីមួយៗ។

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