CASPRIN Capsule

In the treatment of acute myocardial infarction (heart attack), for prevention of heart attack in certain high-risk group patients and for prevention of stroke after transient ischemic attack (TIA). One capsule daily to be taken with a glass of water.

Severe hepatic and renal disease, haemophilia or other bleeding disorders, erosive gastritis or peptic ulcers. Patients who are allergic to aspirin.

The main adverse reactions associated with Aspirin therapy include gastrointestinal distress, nausea, vomiting, erosion of the gastric mucosa, ulceration and occult blood loss.

1.Concurrent administration of Aspirin and dipyridamole may result in an increase in peak plasma-salicylate concentration and area under the curve.

2.Serum-salicylate concentrations may be reduced by concurrent administration of corticosteroids.

3.Aspirin may enhance the activity of coumarin anticoagulant, sulphonylurea, hypoglycaemic agent, methotrexate, phenytoin and valproic acid.

Animals studies have shown that Aspirin can cause birth defects in numerous species. There is no conclusive evidence that Aspirin causes malformation in humans. Drug such as Aspirin inhibit prostaglandin synthesis. When given late in pregnancy, it may cause premature closure of the fetal ductus arteriosus, prolong labour and delay birth. Aspirin increases the bleeding time both in the newborn infant and in the mother because of its antiplatelet effects. Products containing Aspirin should be avoided in late pregnancy.

1. Because of its relatively low dosage and enteric coating dosage form, the risk of Casprin in causing GI ulceration is greatly reduced. However, case should be taken in administering Casprin to patients with prior history of serious GI events.

2. Concurrent use of Casprin with alcoholic beverages should be avoided in order to avoid GI toxicity.

3. Care should be taken when Aspirin is administered to asthmatics patients.

4. Caution is necessary when renal or hepatic function is impaired.

5. The use of Aspirin in children under the age of 16 years is not recommended because of the risk of Reye’s syndrome.

6. Usage in Pregnancy:

Animals studies have shown that Aspirin can cause birth defects in numerous species. There is no conclusive evidence that Aspirin causes malformation in humans. Drug such as Aspirin inhibit prostaglandin synthesis. When given late in pregnancy, it may cause premature closure of the fetal ductus arteriosus, prolong labour and delay birth. Aspirin increases the bleeding time both in the newborn infant and in the mother because of its antiplatelet effects. Products containing Aspirin should be avoided in late pregnancy.

Antiplatelet aggregating effect